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M Blackledge

Explore the profile of M Blackledge including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 661
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Recent Articles
1.
Andreou A, Koh D, Collins D, Blackledge M, Wallace T, Leach M, et al.
Eur Radiol . 2012 Oct; 23(2):428-34. PMID: 23052642
Objective: To determine the measurement reproducibility of perfusion fraction f, pseudodiffusion coefficient D and diffusion coefficient D in colorectal liver metastases and normal liver. Methods: Fourteen patients with known colorectal...
2.
Koh D, Blackledge M, Burns S, Hughes J, Stemmer A, Kiefer B, et al.
Eur Radiol . 2012 Jun; 22(12):2648-53. PMID: 22706913
Objectives: Silicone breast prostheses prove technically challenging when performing diffusion-weighted MR imaging in the breasts. We describe a combined fat and chemical suppression scheme to achieve dual suppression of fat...
3.
Sibille N, Pardi A, Simorre J, Blackledge M
J Am Chem Soc . 2001 Dec; 123(49):12135-46. PMID: 11734011
13C-(1)H residual dipolar couplings (RDC) have been measured for the bases and sugars in the theophylline-binding RNA aptamer, dissolved in filamentous phage medium, and used to investigate the long-range structural...
4.
Dosset P, Hus J, Marion D, Blackledge M
J Biomol NMR . 2001 Aug; 20(3):223-31. PMID: 11519746
Residual dipolar couplings (RDC), measured by dissolving proteins in dilute liquid crystal media, or by studying naturally paramagnetic molecules, have rapidly become established as routine measurements in the investigation of...
5.
Favier A, Blackledge M, Simorre J, Crouzy S, Dabouis V, Gueiffier A, et al.
Biochemistry . 2001 Jul; 40(30):8717-26. PMID: 11467931
The solution structure of the complex formed between d(CGATCG)(2) and 2-(pyrido[1,2-e]purin-4-yl)amino-ethanol, a new antitumor drug under design, has been resolved using NMR spectroscopy and restrained molecular dynamic simulations. The drug...
6.
Hus J, Marion D, Blackledge M
J Am Chem Soc . 2001 Jul; 123(7):1541-2. PMID: 11456746
No abstract available.
7.
Boisbouvier J, Blackledge M, Sollier A, Marion D
J Biomol NMR . 2000 May; 16(3):197-208. PMID: 10805126
Knowledge of the native disulphide bridge topology allows the introduction of conformational restraints between remote parts of the peptide chain. This information is therefore of great importance for the successful...
8.
Hus J, Marion D, Blackledge M
J Mol Biol . 2000 May; 298(5):927-36. PMID: 10801359
Orientational and novel long-range order restraints available from paramagnetic systems have been used to determine the backbone solution structure of the cytochrome c' protein to atomic resolution in the complete...
9.
Guilhaudis L, Simorre J, Blackledge M, Marion D, Gans P, Neuburger M, et al.
Biochemistry . 2000 Apr; 39(15):4259-66. PMID: 10757974
The lipoate containing H-protein plays a pivotal role in the catalytic cycle of the glycine decarboxylase complex (GDC), undergoing reducing methylamination, methylene transfer, and oxidation. The transfer of the CH(2)...
10.
Dosset P, Hus J, Blackledge M, Marion D
J Biomol NMR . 2000 Mar; 16(1):23-8. PMID: 10718609
A novel program has been developed for the interpretation of 15N relaxation rates in terms of macromolecular anisotropic rotational diffusion. The program is based on a highly efficient simulated annealing/minimization...