M A Westerink
Overview
Explore the profile of M A Westerink including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
308
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Recent Articles
1.
Lesinski G, Westerink M
Curr Drug Targets Infect Disord
. 2002 Nov;
1(3):325-34.
PMID: 12455405
Encapsulated bacteria such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae serogroup B (Hib) are a major cause of disease worldwide. Vaccine development against these organisms has targeted their capsular...
2.
Westerink M, Smithson S, Hutchins W, Widera G
Int Rev Immunol
. 2002 Mar;
20(2):251-61.
PMID: 11878768
Anti-idiotypic antibodies and peptides which mimic antigens may offer an alternate strategy for converting a thymus-independent (TI) antigen to a thymus dependent (TD) antigen. We have developed an anti-idiotype based...
3.
Westerink M, Smithson S, Srivastava N, Blonder J, Coeshott C, Rosenthal G
Vaccine
. 2001 Dec;
20(5-6):711-23.
PMID: 11738734
The potential to generate both a systemic and local immune response makes the mucosal system an attractive site for immunization. However, mucosal administration of protein and peptide antigens generally results...
4.
Lesinski G, Westerink M
J Microbiol Methods
. 2001 Sep;
47(2):135-49.
PMID: 11576678
T cell independent antigens do not require T cell help to induce an immune response, and are characterized by a lack of immunologic memory. These antigens can be divided into...
5.
IL-12-mediated increases in protection elicited by pneumococcal and meningococcal conjugate vaccines
Buchanan R, Briles D, Arulanandam B, Westerink M, Raeder R, Metzger D
Vaccine
. 2001 Mar;
19(15-16):2020-8.
PMID: 11228373
Interleukin-12 (IL-12) may be a beneficial adjuvant for augmenting vaccine efficacy against encapsulated bacteria such as Streptococcus pneumoniae and Neisseria meningitidis since it can stimulate production of interferon-gamma (IFN-gamma) and...
6.
Lesinski G, Smithson S, Srivastava N, Chen D, Widera G, Westerink M
Vaccine
. 2001 Feb;
19(13-14):1717-26.
PMID: 11166896
Streptococcus pneumoniae is a leading cause of morbidity and mortality in both the developing and developed world. The T-independent nature of the current polysaccharide vaccine renders it ineffective in elderly...
7.
Srivastava N, Zeiler J, Smithson S, Carlone G, Ades E, Sampson J, et al.
Hybridoma
. 2000 Apr;
19(1):23-31.
PMID: 10768838
Streptococcus pneumoniae is an important pathogen that causes disease in young and elderly individuals. The currently available polysaccharide vaccines have limited efficacy in those age groups most susceptible to pneumococcal...
8.
Grothaus M, Srivastava N, Smithson S, Kieber-Emmons T, Williams D, Carlone G, et al.
Vaccine
. 2000 Jan;
18(13):1253-63.
PMID: 10649627
The presently available meningococcal vaccine is poorly immunogenic in infants and fails to induce long-lasting immunity in adults. Efforts to convert this TI-2 type vaccine into a T dependent vaccine...
9.
Hutchins W, Kieber-Emmons T, Carlone G, Westerink M
Hybridoma
. 1999 Jun;
18(2):121-9.
PMID: 10380011
An anti-idiotype-based peptide mimic vaccine for Neisseria meningitidis serogroup C polysaccharide (MCPS) has been developed and shown to induce a response in mice that is specific, functional, and T-dependent. In...
10.
Smithson S, Srivastava N, Hutchins W, Westerink M
Mol Immunol
. 1999 Jun;
36(2):113-24.
PMID: 10378683
The severe combined immunodeficient (SCID) mouse model, engrafted with human peripheral blood mononuclear cells (hu-PBMC) has proven to be useful in studying the human immune response. A major limitation of...