Lynn D Kramer
Overview
Explore the profile of Lynn D Kramer including associated specialties, affiliations and a list of published articles.
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14
Citations
4988
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Recent Articles
1.
Devanarayan V, Charil A, Horie K, Doherty T, Llano D, Andreozzi E, et al.
Alzheimers Dement
. 2024 Nov;
21(2):e14411.
PMID: 39575854
Background: This study examines whether phosphorylated plasma Tau217 ratio (pTau217R) can predict tau accumulation in different brain regions, as measured by positron emission tomography (PET) standardized uptake value ratio (SUVR),...
2.
Plasma pTau217 predicts continuous brain amyloid levels in preclinical and early Alzheimer's disease
Devanarayan V, Doherty T, Charil A, Sachdev P, Ye Y, Murali L, et al.
Alzheimers Dement
. 2024 Jun;
20(8):5617-5628.
PMID: 38940656
Background: This study investigated the potential of phosphorylated plasma Tau217 ratio (pTau217R) and plasma amyloid beta (Aβ) 42/Aβ40 in predicting brain amyloid levels measured by positron emission tomography (PET) Centiloid...
3.
Berry D, Dhadda S, Kanekiyo M, Li D, Swanson C, Irizarry M, et al.
JAMA Netw Open
. 2023 Apr;
6(4):e237230.
PMID: 37040116
Importance: Bayesian clinical trial designs are increasingly common; given their promotion by the US Food and Drug Administration, the future use of the bayesian approach will only continue to increase....
4.
Honig L, Barakos J, Dhadda S, Kanekiyo M, Reyderman L, Irizarry M, et al.
Alzheimers Dement (N Y)
. 2023 Mar;
9(1):e12377.
PMID: 36949897
Introduction: Lecanemab is a humanized immunoglobulin G1 (IgG1) monoclonal antibody that preferentially targets soluble aggregated Aβ species (protofibrils) with activity at amyloid plaques. Amyloid-related imaging abnormalities (ARIA) profiles appear to...
5.
McDade E, Cummings J, Dhadda S, Swanson C, Reyderman L, Kanekiyo M, et al.
Alzheimers Res Ther
. 2022 Dec;
14(1):191.
PMID: 36544184
Background: Lecanemab, a humanized IgG1 monoclonal antibody that targets soluble aggregated Aβ species (protofibrils), has demonstrated robust brain fibrillar amyloid reduction and slowing of clinical decline in early AD. The...
6.
Dhadda S, Kanekiyo M, Li D, Swanson C, Irizarry M, Berry S, et al.
Alzheimers Res Ther
. 2022 Dec;
14(1):182.
PMID: 36482412
Background: Lecanemab (BAN2401) is a humanized IgG1 monoclonal antibody that preferentially targets soluble aggregated Aβ species (protofibrils) with activity at insoluble fibrils and slowed clinical decline in an 18-month phase...
7.
van Dyck C, Swanson C, Aisen P, Bateman R, Chen C, Gee M, et al.
N Engl J Med
. 2022 Nov;
388(1):9-21.
PMID: 36449413
Background: The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may initiate or potentiate pathologic processes in Alzheimer's disease. Lecanemab, a humanized IgG1 monoclonal antibody that binds with high affinity...
8.
Rafii M, Sperling R, Donohue M, Zhou J, Roberts C, Irizarry M, et al.
Alzheimers Dement
. 2022 Aug;
19(4):1227-1233.
PMID: 35971310
Introduction: The Alzheimer's disease (AD) continuum begins with a long asymptomatic or preclinical stage, during which amyloid beta (Aβ) is accumulating for more than a decade prior to widespread cortical...
9.
Swanson C, Zhang Y, Dhadda S, Wang J, Kaplow J, Lai R, et al.
Alzheimers Res Ther
. 2022 May;
14(1):70.
PMID: 35598024
No abstract available.
10.
Swanson C, Zhang Y, Dhadda S, Wang J, Kaplow J, Lai R, et al.
Alzheimers Res Ther
. 2021 Apr;
13(1):80.
PMID: 33865446
Background: Lecanemab (BAN2401), an IgG1 monoclonal antibody, preferentially targets soluble aggregated amyloid beta (Aβ), with activity across oligomers, protofibrils, and insoluble fibrils. BAN2401-G000-201, a randomized double-blind clinical trial, utilized a...