Lyle Moldawer
Overview
Explore the profile of Lyle Moldawer including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
20
Citations
403
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Guirgis F, Black L, Henson M, Bertrand A, DeVos E, Ferreira J, et al.
Crit Care Med
. 2024 Mar;
52(8):1183-1193.
PMID: 38488429
Objectives: Low cholesterol levels in early sepsis patients are associated with mortality. We sought to test if IV lipid emulsion administration to sepsis patients with low cholesterol levels would prevent...
2.
Guirgis F, Black L, Henson M, Labilloy G, Smotherman C, Hopson C, et al.
Crit Care
. 2021 Sep;
25(1):341.
PMID: 34535154
Objective: Approximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay > 14 days) or early death (in-hospital death within 14 days)....
3.
Miranda D, Maine R, Cook M, Brakenridge S, Moldawer L, Arbabi S, et al.
Trauma Surg Acute Care Open
. 2021 Aug;
6(1):e000747.
PMID: 34423134
Objectives: Chronic critical illness (CCI) is a phenotype that occurs frequently in patients with severe injury. Previous work has suggested that inflammatory changes leading to CCI occur early following injury....
4.
Guirgis F, Leeuwenburgh C, Moldawer L, Ghita G, Black L, Henson M, et al.
Ann Intensive Care
. 2021 May;
11(1):82.
PMID: 34018068
Rationale: Sepsis is a life-threatening, dysregulated response to infection. Lipid biomarkers including cholesterol are dynamically regulated during sepsis and predict short-term outcomes. In this study, we investigated the predictive ability...
5.
Barker G, Leeuwenburgh C, Brusko T, Moldawer L, Reddy S, Guirgis F
J Clin Med
. 2021 Apr;
10(8).
PMID: 33920038
In addition to their well-characterized roles in metabolism, lipids and lipoproteins have pleiotropic effects on the innate immune system. These undergo clinically relevant alterations during sepsis and acute inflammatory responses....
6.
Guirgis F, Black L, DeVos E, Henson M, Ferreira J, Miller T, et al.
J Am Coll Emerg Physicians Open
. 2021 Jan;
1(6):1332-1340.
PMID: 33392541
Objectives: Cholesterol may be protective in sepsis. Patients with early sepsis may have critically low cholesterol levels that are associated with poor outcomes. The study objective was to test the...
7.
Bandyopadhyay S, Lysak N, Adhikari L, Velez L, Sautina L, Mohandas R, et al.
Crit Care Explor
. 2020 Oct;
2(10):e0195.
PMID: 33063018
Design: Prospective cohort study. Setting: Quaternary care academic hospital. Patients: A total of 266 sepsis and 82 control patients enrolled between January 2015 and February 2018. Interventions: Whole-genome transcriptomic analysis...
8.
Guirgis F, Dodani S, Leeuwenburgh C, Moldawer L, Bowman J, Kalynych C, et al.
PLoS One
. 2018 Sep;
13(9):e0203813.
PMID: 30216360
Objective: High density lipoprotein (HDL) is important for defense against sepsis but becomes dysfunctional (Dys-HDL) during inflammation. We hypothesize that Dys-HDL correlates with organ dysfunction (sequential organ failure assessment (SOFA)...
9.
Zingarelli B, Coopersmith C, Drechsler S, Efron P, Marshall J, Moldawer L, et al.
Shock
. 2018 Aug;
51(1):10-22.
PMID: 30106874
Preclinical animal studies are mandatory before new treatments can be tested in clinical trials. However, their use in developing new therapies for sepsis has been controversial because of limitations of...
10.
Remick D, Ayala A, Chaudry I, Coopersmith C, Deutschman C, Hellman J, et al.
Shock
. 2018 Jun;
51(1):4-9.
PMID: 29877959
Sepsis morbidity and mortality exacts a toll on patients and contributes significantly to healthcare costs. Preclinical models of sepsis have been used to study disease pathogenesis and test new therapies,...