Luke A Wiley
Overview
Explore the profile of Luke A Wiley including associated specialties, affiliations and a list of published articles.
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49
Citations
1089
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Recent Articles
1.
Burnight E, Wiley L, Mullin N, Adur M, Lang M, Cranston C, et al.
CRISPR J
. 2023 Dec;
6(6):502-513.
PMID: 38108516
Rhodopsin () mutations such as Pro23His are the leading cause of dominantly inherited retinitis pigmentosa in North America. As with other dominant retinal dystrophies, these mutations lead to production of...
2.
Wiley L, Boyce T, Meyering E, Ochoa D, Sheehan K, Stone E, et al.
Hum Gene Ther
. 2023 Feb;
34(11-12):530-539.
PMID: 36793189
Adeno-associated virus (AAV)-mediated gene therapy has great potential for treating a wide range of retinal degenerative diseases. However, some initial enthusiasm for gene therapy has been tempered by emerging evidence...
3.
Han I, Wiley L, Ochoa D, Lang M, Harman B, Sheehan K, et al.
Gene Ther
. 2022 Sep;
30(3-4):362-368.
PMID: 36175490
In humans, mutations in the beta subunit of cGMP-phosphodiesterase type 6 (PDE6B) cause autosomal recessive retinitis pigmentosa (RP), which typically has an aggressive clinical course of early-onset severe vision loss...
4.
Han I, Bohrer L, Gibson-Corley K, Wiley L, Shrestha A, Harman B, et al.
Cell Transplant
. 2022 Jun;
31:9636897221104451.
PMID: 35758274
Loss of photoreceptor cells is a primary feature of inherited retinal degenerative disorders including age-related macular degeneration and retinitis pigmentosa. To restore vision in affected patients, photoreceptor cell replacement will...
5.
Voigt A, Mullin N, Mulfaul K, Lozano L, Wiley L, Flamme-Wiese M, et al.
Hum Mol Genet
. 2022 Feb;
31(14):2406-2423.
PMID: 35181781
The human choroid is a heterogeneous, highly vascular connective tissue that dysfunctions in age-related macular degeneration (AMD). In this study, we performed single-cell RNA sequencing on 21 human choroids, 11...
6.
Han I, Burnight E, Kaalberg E, Boyce T, Stone E, Fingert J, et al.
J Ocul Pharmacol Ther
. 2021 Oct;
37(10):575-579.
PMID: 34597181
Despite numerous recent advances in retinal gene therapy using adeno-associated viruses (AAVs) as delivery vectors, there remains a crucial need to identify viral vectors with the ability to transduce specific...
7.
Tucker B, Burnight E, Cranston C, Ulferts M, Luse M, Westfall T, et al.
Gene Ther
. 2021 Sep;
29(5):259-288.
PMID: 34518651
By combining next generation whole exome sequencing and induced pluripotent stem cell (iPSC) technology we found that an Alu repeat inserted in exon 9 of the MAK gene results in...
8.
Wendland R, Jiao C, Russell S, Han I, Wiley L, Tucker B, et al.
Exp Eye Res
. 2021 Apr;
207:108566.
PMID: 33838142
Emerging treatment strategies for retinal degeneration involve replacing lost photoreceptors using supportive scaffolds to ensure cells survive the implantation process. While many design aspects of these scaffolds, including material chemistry...
9.
Han I, Cheng J, Burnight E, Ralston C, Fick J, Thomsen G, et al.
Hum Gene Ther
. 2020 Sep;
31(23-24):1288-1299.
PMID: 32948113
Viral-mediated gene augmentation offers tremendous promise for the treatment of inherited retinal diseases. The development of effective gene therapy requires an understanding of the vector's tissue-specific behavior, which may vary...
10.
Wiley L, Binkley E, DeLuca A, Workalemahu G, Tatro N, Luse M, et al.
Retin Cases Brief Rep
. 2019 Nov;
16(1):111-117.
PMID: 31764884
Purpose: 1) To describe a case of autoimmune retinopathy mimicking heritable photoreceptor degeneration in a patient with common variable immune deficiency and 2) to investigate the humoral and cell-mediated branches...