Lukas M Orre
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Explore the profile of Lukas M Orre including associated specialties, affiliations and a list of published articles.
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29
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764
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Recent Articles
1.
Pan Y, Berkovska O, Marathe S, Mermelekas G, Gudoityte G, Wolide A, et al.
iScience
. 2025 Feb;
28(2):111864.
PMID: 39995872
Farnesylation is a lipid post-translational modification of proteins crucial for protein membrane anchoring and cellular signaling. Farnesyltransferase inhibitors (FTIs), such as tipifarnib, are being tested in cancer therapy. However, the...
2.
Hagerstrand D, Oder B, Cortese D, Qu Y, Binzer-Panchal A, Osterholm C, et al.
Leukemia
. 2024 Sep;
38(11):2429-2442.
PMID: 39261602
SF3B1 mutations are recurrent in chronic lymphocytic leukemia (CLL), particularly enriched in clinically aggressive stereotyped subset #2. To investigate their impact, we conducted RNA-sequencing of 18 SF3B1 and 17 SF3B1...
3.
Long Jr D, Chan M, Han M, Kamdar Z, Ma R, Tsai P, et al.
Cell Rep Med
. 2024 Aug;
5(9):101699.
PMID: 39208801
Fibrolamellar carcinoma (FLC) is a rare, lethal, early-onset liver cancer with a critical need for new therapeutics. The primary driver in FLC is the fusion oncoprotein, DNAJ-PKAc, which remains challenging...
4.
Struyf N, Osterroos A, Vesterlund M, Arnroth C, James T, Sunandar S, et al.
NPJ Precis Oncol
. 2024 Feb;
8(1):38.
PMID: 38374206
Consistent handling of samples is crucial for achieving reproducible molecular and functional testing results in translational research. Here, we used 229 acute myeloid leukemia (AML) patient samples to assess the...
5.
Brunner A, Li Q, Fisicaro S, Kourtesakis A, Viiliainen J, Johansson H, et al.
Mol Cell
. 2023 Aug;
83(20):3720-3739.e8.
PMID: 37591242
Fanconi anemia (FA) signaling, a key genomic maintenance pathway, is activated in response to replication stress. Here, we report that phosphorylation of the pivotal pathway protein FANCD2 by CHK1 triggers...
6.
Trac Q, Pawitan Y, Mou T, Erkers T, Ostling P, Bohlin A, et al.
NPJ Precis Oncol
. 2023 Mar;
7(1):32.
PMID: 36964195
Despite some encouraging successes, predicting the therapy response of acute myeloid leukemia (AML) patients remains highly challenging due to tumor heterogeneity. Here we aim to develop and validate MDREAM, a...
7.
Arslan T, Pan Y, Mermelekas G, Vesterlund M, Orre L, Lehtio J
Nat Protoc
. 2022 Jun;
17(8):1832-1867.
PMID: 35732783
The molecular functions of a protein are defined by its inherent properties in relation to its environment and interaction network. Within a cell, this environment and network are defined by...
8.
Lehtio J, Arslan T, Siavelis I, Pan Y, Socciarelli F, Berkovska O, et al.
Nat Cancer
. 2021 Dec;
2(11):1224-1242.
PMID: 34870237
Despite major advancements in lung cancer treatment, long-term survival is still rare, and a deeper understanding of molecular phenotypes would allow the identification of specific cancer dependencies and immune evasion...
9.
Veerman R, Teeuwen L, Czarnewski P, Akpinar G, Sandberg A, Cao X, et al.
J Extracell Vesicles
. 2021 Jul;
10(9):e12128.
PMID: 34322205
Extracellular vesicles (EVs) are increasingly tested as therapeutic vehicles and biomarkers, but still EV subtypes are not fully characterised. To isolate EVs with few co-isolated entities, a combination of methods...
10.
Mou T, Pawitan Y, Stahl M, Vesterlund M, Deng W, Jafari R, et al.
Am J Hematol
. 2021 Feb;
96(5):580-588.
PMID: 33625756
Molecular classification of acute myeloid leukemia (AML) aids prognostic stratification and clinical management. Our aim in this study is to identify transcriptome-wide mRNAs that are specific to each of the...