Luis Hortells
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Explore the profile of Luis Hortells including associated specialties, affiliations and a list of published articles.
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12
Citations
255
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Recent Articles
1.
Haider S, Sassu E, Stefanovska D, Stoyek M, Preissl S, Hortells L
Ageing Res Rev
. 2025 Feb;
105:102690.
PMID: 39947485
Aging strongly affects the peripheral nervous system (PNS), triggering alterations that vary depending on the innervated tissue. The most frequent alteration in peripheral nerve aging is reduced nerve fiber and...
2.
Cuevas R, Hortells L, Chu C, Wong R, Crane A, Boufford C, et al.
Circ Res
. 2025 Jan;
136(4):403-421.
PMID: 39835393
Background: Calcific aortic valve disease is the pathological remodeling of valve leaflets. The initial steps in valve leaflet osteogenic reprogramming are not fully understood. As TERT (telomerase reverse transcriptase) overexpression...
3.
Sassu E, Tumlinson G, Stefanovska D, Fernandez M, Iaconianni P, Madl J, et al.
J Mol Cell Cardiol
. 2023 Dec;
187:1-14.
PMID: 38103633
Background: Although aging is known to be associated with an increased incidence of both atrial and ventricular arrhythmias, there is limited knowledge about how Schwann cells (SC) and the intracardiac...
4.
Stoyek M, Hortells L, Quinn T
J Cardiovasc Dev Dis
. 2021 Nov;
8(11).
PMID: 34821702
The intracardiac nervous system (IcNS), sometimes referred to as the "little brain" of the heart, is involved in modulating many aspects of cardiac physiology. In recent years our fundamental understanding...
5.
Hortells L, Meyer E, Thomas Z, Yutzey K
J Mol Cell Cardiol
. 2021 Feb;
154:124-136.
PMID: 33582160
Background: The intracardiac nervous system (ICNS) is composed of neurons, in association with Schwann cells (SC) and endoneurial cardiac fibroblasts (ECF). Besides heart rhythm control, recent studies have implicated cardiac...
6.
Hortells L, Valiente-Alandi I, Thomas Z, Agnew E, Schnell D, York A, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(35):21469-21479.
PMID: 32817558
During the postnatal period in mammals, the cardiac muscle transitions from hyperplasic to hypertrophic growth, the extracellular matrix (ECM) undergoes remodeling, and the heart loses regenerative capacity. While ECM maturation...
7.
Hortells L, Guillen N, Sosa C, Sorribas V
Am J Physiol Heart Circ Physiol
. 2019 Dec;
318(2):H448-H460.
PMID: 31886722
We have studied inorganic phosphate (P) handling in rat aortic vascular smooth muscle cells (VSMC) using P-radiotracer assays. Our results have revealed a complex set of mechanisms consisting of )...
8.
Agnew E, Velayutham N, Matos Ortiz G, Alfieri C, Hortells L, Moore V, et al.
J Cardiovasc Dev Dis
. 2019 Dec;
7(1).
PMID: 31861331
Studies in mice show a brief neonatal period of cardiac regeneration with minimal scar formation, but less is known about reparative mechanisms in large mammals. A transient cardiac injury approach...
9.
Hortells L, Johansen A, Yutzey K
J Cardiovasc Dev Dis
. 2019 Aug;
6(3).
PMID: 31434209
During the postnatal period in mammals, the heart undergoes significant remodeling and cardiac cells progressively lose their embryonic characteristics. At the same time, notable changes in the extracellular matrix (ECM)...
10.
Hulin A, Hortells L, Gomez-Stallons M, ODonnell A, Chetal K, Adam M, et al.
Development
. 2019 Feb;
146(12).
PMID: 30796046
Heart valve cells mediate extracellular matrix (ECM) remodeling during postnatal valve leaflet stratification, but phenotypic and transcriptional diversity of valve cells in development is largely unknown. Single cell analysis of...