Luis E B Bettio
Overview
Explore the profile of Luis E B Bettio including associated specialties, affiliations and a list of published articles.
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32
Citations
958
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Recent Articles
1.
Life B, Bettio L, Gantois I, Christie B, Leavitt B
Curr Res Neurobiol
. 2023 Jul;
5:100094.
PMID: 37416094
A growing body of evidence has implicated progranulin in neurodevelopment and indicated that aberrant progranulin expression may be involved in neurodevelopmental disease. Specifically, increased progranulin expression in the prefrontal cortex...
2.
Camargo A, Bettio L, Rosa P, Rosa J, Alte G, Rodrigues A
Purinergic Signal
. 2022 Sep;
19(2):387-399.
PMID: 36166131
Guanosine has been considered a promising candidate for antidepressant responses, but if this nucleoside could modulate adenosine A (AR) and A (AR) receptors to exert antidepressant-like actions remains to be...
3.
Islam M, Valaris S, Young M, Haley E, Luo R, Bond S, et al.
Nat Metab
. 2021 Oct;
3(10):1432.
PMID: 34621079
No abstract available.
4.
Islam M, Valaris S, Young M, Haley E, Luo R, Bond S, et al.
Nat Metab
. 2021 Aug;
3(8):1058-1070.
PMID: 34417591
Identifying secreted mediators that drive the cognitive benefits of exercise holds great promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here, we show that irisin,...
5.
Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling
Rosa P, Bettio L, Neis V, Moretti M, Kaufmann F, Tavares M, et al.
Purinergic Signal
. 2021 Mar;
17(2):285-301.
PMID: 33712981
Guanosine is a purine nucleoside that has been shown to exhibit antidepressant effects, but the mechanisms underlying its effect are not well established. We investigated if the antidepressant-like effect induced...
6.
Bettio L, Thacker J, Rodgers S, Brocardo P, Christie B, Gil-Mohapel J
Biochim Biophys Acta Mol Basis Dis
. 2020 May;
1866(8):165821.
PMID: 32376385
The hippocampus is a brain structure known to play a central role in cognitive function (namely learning and memory) as well as mood regulation and affective behaviors due in part...
7.
Rosa P, Bettio L, Neis V, Moretti M, Werle I, Leal R, et al.
Purinergic Signal
. 2019 Nov;
15(4):491-504.
PMID: 31768875
Although guanosine is an endogenous nucleoside that displays antidepressant-like properties in several animal models, the mechanism underlying its antidepressant-like effects is not well characterized. The present study aimed at investigating...
8.
Galts C, Bettio L, Jewett D, Yang C, Brocardo P, Rodrigues A, et al.
Neurosci Biobehav Rev
. 2019 Apr;
102:56-84.
PMID: 30995512
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major cause of disability worldwide. This neurological condition is commonly associated with neurodegenerative diseases such as Alzheimer's disease...
9.
Ghilan M, Bettio L, Noonan A, Brocardo P, Gil-Mohapel J, Christie B
Behav Brain Res
. 2018 May;
350:72-79.
PMID: 29778627
Fragile X syndrome (FXS) is the most common form of inherited intellectual impairment. The Fmr1 mouse model has been previously shown to have deficits in context discrimination tasks but not...
10.
Bettio L, Gil-Mohapel J, Patten A, ORourke N, Hanley R, Gopalakrishnan K, et al.
Neurogenesis (Austin)
. 2017 Jun;
4(1):e1317692.
PMID: 28656155
The development of synthetic small molecules capable of promoting neuronal fate in stem cells is a promising strategy to prevent the decline of hippocampal function caused by several neurological disorders....