Lucia Sladekova
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Explore the profile of Lucia Sladekova including associated specialties, affiliations and a list of published articles.
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5
Citations
18
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Recent Articles
1.
Wang X, Zhang G, Bian Z, Chow V, Grimaldi M, Carivenc C, et al.
Nat Commun
. 2025 Mar;
16(1):2133.
PMID: 40032830
No abstract available.
2.
Sladekova L, Li H, DesMarais V, Beck A, Guzik H, Vyhlidalova B, et al.
J Pharmacol Exp Ther
. 2025 Mar;
392(2):100059.
PMID: 40023602
Chronic intestinal inflammation significantly contributes to the development of colorectal cancer and remains a pertinent clinical challenge, necessitating novel therapeutic approaches. Indole-based microbial metabolite mimics Felix Kopp Kortagere 6 (FKK6),...
3.
Wang X, Zhang G, Bian Z, Chow V, Grimaldi M, Carivenc C, et al.
Nat Commun
. 2025 Feb;
16(1):1280.
PMID: 39900639
The literature documenting the value of drug-like molecules found in natural products is vast. Although many dietary and herbal remedies have been found to be effective for treating intestinal inflammation,...
4.
Sladekova L, Li H, DesMarais V, Beck A, Guzik H, Vyhlidalova B, et al.
bioRxiv
. 2024 Aug;
PMID: 39211241
Chronic intestinal inflammation significantly contributes to the development of colorectal cancer (CRC) and remains a pertinent clinical challenge, necessitating novel therapeutic approaches. Indole-based microbial metabolite mimics FKK6, which is a...
5.
Sladekova L, Zgarbova E, Vrzal R, Vanda D, Soural M, Jakubcova K, et al.
Toxicol Lett
. 2023 Oct;
387:63-75.
PMID: 37778463
Microbial indoles have been demonstrated as selective or dual agonists and ligands of the pregnane X receptor (PXR) and aryl hydrocarbon receptor (AhR). However, structural determinants of microbial indoles selectivity...
6.
Sladekova L, Mani S, Dvorak Z
Biochem Pharmacol
. 2023 May;
213:115626.
PMID: 37247746
The aryl hydrocarbon receptor (AhR) belongs to the essential helix-loop-helix transcription factors family. This receptor has a central role in determining host physiology and a variety of pathophysiologies ranging from...
7.
Grycova A, Joo H, Maier V, Illes P, Vyhlidalova B, Poulikova K, et al.
J Med Chem
. 2022 Apr;
65(9):6859-6868.
PMID: 35416668
Targeting the aryl hydrocarbon receptor (AhR) is an emerging therapeutic strategy for multiple diseases (e.g., inflammatory bowel disease). microbial metabolite 2-(1'-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) is a putative AhR endogenous...
8.
Dolezalova A, Sladekova L, Simonikova D, Holusova K, Karafiatova M, Varshney R, et al.
Front Plant Sci
. 2022 Feb;
12:791303.
PMID: 35145533
Chickpea ( L.) is one of the main sources of plant proteins in the Indian subcontinent and West Asia, where two different morphotypes, desi and kabuli, are grown. Despite the...