Lucas J Bailey
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Explore the profile of Lucas J Bailey including associated specialties, affiliations and a list of published articles.
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20
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433
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Recent Articles
1.
Watkins E, Antane J, Roberts J, Lorentz K, Zuerndorfer S, Dunaif A, et al.
Sci Immunol
. 2021 Feb;
6(56).
PMID: 33637595
Although most current treatments for autoimmunity involve broad immunosuppression, recent efforts have aimed to suppress T cells in an antigen-specific manner to minimize risk of infection. One such effort is...
2.
Slezak T, Bailey L, Jaskolowski M, Nahotko D, Filippova E, Davydova E, et al.
Protein Sci
. 2019 Oct;
29(1):141-156.
PMID: 31622515
Engineered recombinant antibody-based reagents are rapidly supplanting traditionally derived antibodies in many cell biological applications. A particularly powerful aspect of these engineered reagents is that other modules having myriad functions...
3.
Farcasanu M, Wang A, Uchanski T, Bailey L, Yue J, Chen Z, et al.
Biochemistry
. 2019 Jun;
58(27):2996-3004.
PMID: 31243996
Anthrax, a lethal, weaponizable disease caused by Bacillus anthracis, acts through exotoxins that are primary mediators of systemic toxicity and also targets for neutralization by passive immunotherapy. The ease of...
4.
Zhang Z, Liang W, Bailey L, Tan Y, Wei H, Wang A, et al.
Elife
. 2018 Mar;
7.
PMID: 29596046
Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two diabetes, Alzheimer's, inflammation, and other human diseases. However, the process through which IDE recognizes peptides that...
5.
Koirala D, Shelke S, Dupont M, Ruiz S, DasGupta S, Bailey L, et al.
Nucleic Acids Res
. 2018 Jan;
46(5):2624-2635.
PMID: 29309709
Antibody fragments such as Fabs possess properties that can enhance protein and RNA crystallization and therefore can facilitate macromolecular structure determination. In particular, Fab BL3-6 binds to an AAACA RNA...
6.
Bailey L, Sheehy K, Dominik P, Liang W, Rui H, Clark M, et al.
J Mol Biol
. 2017 Dec;
430(3):337-347.
PMID: 29273204
Antibody Fab fragments have been exploited with significant success to facilitate the structure determination of challenging macromolecules as crystallization chaperones and as molecular fiducial marks for single particle cryo-electron microscopy...
7.
Acheson J, Bailey L, Brunold T, Fox B
Nature
. 2017 Mar;
544(7649):191-195.
PMID: 28346937
Electrophilic aromatic substitution is one of the most important and recognizable classes of organic chemical transformation. Enzymes create the strong electrophiles that are needed for these highly energetic reactions by...
8.
Schaefer Z, Bailey L, Kossiakoff A
Protein Sci
. 2016 Jun;
25(7):1290-8.
PMID: 27334407
Engineering monovalent Fab fragments into bivalent formats like IgGs or F(ab')2 can lead to aggregation presumably because of nonspecific off-target interactions that induce aggregation. In an effort to further understand...
9.
Bailey L, Sheehy K, Hoey R, Schaefer Z, Ura M, Kossiakoff A
J Immunol Methods
. 2014 Dec;
415:24-30.
PMID: 25450256
Immunoglobulin binding proteins (IBPs) are broadly used as reagents for the purification and detection of antibodies. Among the IBPs, the most widely used are Protein-A and Protein-G. The C2 domain...
10.
Structural basis for biomolecular recognition in overlapping binding sites in a diiron enzyme system
Acheson J, Bailey L, Elsen N, Fox B
Nat Commun
. 2014 Sep;
5:5009.
PMID: 25248368
Productive biomolecular recognition requires exquisite control of affinity and specificity. Accordingly, nature has devised many strategies to achieve proper binding interactions. Bacterial multicomponent monooxygenases provide a fascinating example, where a...