Lucas A Gillenwater
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Explore the profile of Lucas A Gillenwater including associated specialties, affiliations and a list of published articles.
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10
Citations
157
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Recent Articles
1.
Gillenwater L, Galbraith M, Rachubinski A, Eduthan N, Sullivan K, Espinosa J, et al.
Sci Adv
. 2024 Dec;
10(50):eadq3073.
PMID: 39671500
Down syndrome (DS), caused by trisomy 21 (T21), results in immune and metabolic dysregulation. People with DS experience co-occurring conditions at higher rates than the euploid population. However, the interplay...
2.
Nandi S, Zhu Y, Gillenwater L, Subirana-Granes M, Zhang H, Janani N, et al.
Pac Symp Biocomput
. 2024 Dec;
30:412-425.
PMID: 39670386
Down syndrome (DS), caused by the triplication of chromosome 21 (T21), is a prevalent genetic disorder with a higher incidence of obesity. Traditional approaches have struggled to differentiate T21-specific molecular...
3.
Callahan T, Tripodi I, Stefanski A, Cappelletti L, Taneja S, Wyrwa J, et al.
Sci Data
. 2024 Apr;
11(1):363.
PMID: 38605048
Translational research requires data at multiple scales of biological organization. Advancements in sequencing and multi-omics technologies have increased the availability of these data, but researchers face significant integration challenges. Knowledge...
4.
Santangelo B, Gillenwater L, Salem N, Hunter L
Front Bioinform
. 2022 Dec;
2:1054578.
PMID: 36568701
Molecular "cartoons," such as pathway diagrams, provide a visual summary of biomedical research results and hypotheses. Their ubiquitous appearance within the literature indicates their universal application in mechanistic communication. A...
5.
Gillenwater L, Helmi S, Stene E, Pratte K, Zhuang Y, Schuyler R, et al.
PLoS One
. 2021 Aug;
16(8):e0255337.
PMID: 34432807
Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of mortality in the United States; however, COPD has heterogeneous clinical phenotypes. This is the first large scale attempt which...
6.
Gillenwater L, Pratte K, Hobbs B, Cho M, Zhuang Y, Halper-Stromberg E, et al.
Netw Syst Med
. 2021 May;
3(1):159-181.
PMID: 33987620
Small studies have recently suggested that there are specific plasma metabolic signatures in chronic obstructive pulmonary disease (COPD), but there have been no large comprehensive study of metabolomic signatures in...
7.
Pratte K, Curtis J, Kechris K, Couper D, Cho M, Silverman E, et al.
Respir Res
. 2021 Apr;
22(1):127.
PMID: 33906653
Background: Soluble receptor for advanced glycation end products (sRAGE) is a proposed emphysema and airflow obstruction biomarker; however, previous publications have shown inconsistent associations and only one study has investigate...
8.
Gillenwater L, Kechris K, Pratte K, Reisdorph N, Petrache I, Labaki W, et al.
Metabolites
. 2021 Apr;
11(3).
PMID: 33799786
Susceptibility and progression of lung disease, as well as response to treatment, often differ by sex, yet the metabolic mechanisms driving these sex-specific differences are still poorly understood. Women with...
9.
Schweitzer K, Jinawath N, Yonescu R, Ni K, Rush N, Charoensawan V, et al.
JCI Insight
. 2020 Jun;
5(14).
PMID: 32573489
Cigarette smoking (CS) and genetic susceptibility determine the risk for development, progression, and severity of chronic obstructive pulmonary diseases (COPD). We posited that an incidental balanced reciprocal chromosomal translocation was...
10.
Raffield L, Dang H, Pratte K, Jacobson S, Gillenwater L, Ampleford E, et al.
Proteomics
. 2020 May;
20(12):e1900278.
PMID: 32386347
Novel proteomics platforms, such as the aptamer-based SOMAscan platform, can quantify large numbers of proteins efficiently and cost-effectively and are rapidly growing in popularity. However, comparisons to conventional immunoassays remain...