Lucas A D Nicolau
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Explore the profile of Lucas A D Nicolau including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
132
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Recent Articles
11.
Nogueira K, de Souza L, de Oliveira A, Pacheco G, Iles B, Alencar M, et al.
Drug Dev Res
. 2019 May;
80(5):666-679.
PMID: 31112325
Inflammation is the response of the body to noxious stimuli such as infections, trauma, or injury. Experimental studies have shown that vanillic acid has anti-inflammatory effects. The objective of this...
12.
Araujo S, Oliveira A, Sousa F, Souza L, Pacheco G, Filgueiras M, et al.
Nitric Oxide
. 2018 Jun;
78:60-71.
PMID: 29857061
Activation of 5' adenosine monophosphate-activated protein kinase (AMPK) stimulates production of the gaseous mediators nitric oxide (NO) and carbon monoxide (CO), which are involved in mucosal defense and gastroprotection. As...
13.
Figueiredo A, Santana A, Nicolau L, Batista-Lima F, V T Wong D, Lucetti L, et al.
Laryngoscope
. 2017 Oct;
128(5):1157-1162.
PMID: 29076531
Objectives/hypothesis: Evaluate the effect of in vitro exposure of mice laryngeal mucosa to solutions that simulated human gastric juice and to assess the topical protective effect of cashew gum on...
14.
Sousa F, Souza L, Sousa N, Araujo T, Araujo S, Pacifico D, et al.
Nitric Oxide
. 2017 Sep;
76:152-163.
PMID: 28943473
Hydrogen sulphide (HS) is a gasotransmitter that participates in various physiological and pathophysiological processes within the gastrointestinal tract. We studied the effects and possible mechanism of action of HS in...
15.
Silva I, Nicolau L, Sousa F, Araujo S, Oliveira A, Araujo T, et al.
Int J Biol Macromol
. 2017 Jul;
105(Pt 1):1105-1116.
PMID: 28751047
Inflammation is a protective reaction of the microcirculation. However, sustained inflammation can lead to undesired effects. Thuja occidentalis Linn has many pharmacological properties but has no anti-inflammatory activity described. Thus,...
16.
de Oliveira G, da Silva Oliveira G, Nicolau L, Mafud A, Batista L, Mascarenhas Y, et al.
Med Chem
. 2017 Mar;
13(6):592-603.
PMID: 28266277
Background: Bergenin, a compound derived from gallic acid, is a secondary metabolite of the plant Peltophorum dubium (Spreng.) Taub. Objective: In this study, we aimed to characterize the ability of...
17.
Souza L, Araujo T, Sousa N, Sousa F, Nogueira K, Nicolau L, et al.
Nitric Oxide
. 2017 Feb;
64:1-6.
PMID: 28137610
Hydrogen sulfide (HS) is a signaling molecule in the gastrointestinal tract. HS production can derive from d-cysteine via various pathways, thus pointing to a new therapeutic approach: delivery of HS...
18.
Nicolau L, Carvalho N, Pacifico D, Lucetti L, Aragao K, Veras L, et al.
Biomed Pharmacother
. 2017 Jan;
87:188-195.
PMID: 28056423
Objective: This study aimed to investigate the protective effect of epiisopiloturine hydrochloride (EPI), an imidazole alkaloid, on NAP-induced gastrointestinal damage in rats. Methods: Initially, rats were pretreated with 0.5% carboxymethylcellulose...
19.
Souza L, Nicolau L, Sousa N, Araujo T, Sousa F, Costa D, et al.
Biochem Pharmacol
. 2016 Jun;
112:50-9.
PMID: 27241079
The angiotensin (Ang) II converting enzyme (ACE II) pathway has recently been shown to be associated with several beneficial effects in various organisms, including gastroprotection. ACE II is responsible for...
20.
Costa D, Araujo T, Sousa N, Souza L, Pacifico D, Sousa F, et al.
Basic Clin Pharmacol Toxicol
. 2015 Nov;
118(6):440-8.
PMID: 26582552
Diarrhoea is a significant health problem for children in developing countries that causes more than 1 million deaths annually. This study aimed to evaluate the antidiarrhoeal effect of sulphated polysaccharide...