Luca Rima
Overview
Explore the profile of Luca Rima including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
48
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Recent Articles
1.
Single and few cell analysis for correlative light microscopy, metabolomics, and targeted proteomics
Rima L, Berchtold C, Arnold S, Frankl A, Sutterlin R, Dernick G, et al.
Lab Chip
. 2024 Aug;
24(18):4321-4332.
PMID: 39132885
The interactions of proteins, membranes, nucleic acid, and metabolites shape a cell's phenotype. These interactions are stochastic, and each cell develops differently, making it difficult to synchronize cell populations. Consequently,...
2.
Rima L, Zimmermann M, Frankl A, Clairfeuille T, Lauer M, Engel A, et al.
Faraday Discuss
. 2022 Aug;
240(0):55-66.
PMID: 35924676
Electron microscopy (EM) introduced a fast and lasting change to structural and cellular biology. However, the sample preparation is still the bottleneck in the cryogenic electron microscopy (cryo-EM) workflow. Classical...
3.
Syntychaki A, Rima L, Schmidli C, Stohler T, Bieri A, Sutterlin R, et al.
J Proteome Res
. 2019 Jul;
18(9):3521-3531.
PMID: 31355640
Proteins are involved in all tasks of life, and their characterization is essential to understand the underlying mechanisms of biological processes. We present a method called "differential visual proteomics" geared...
4.
Schmidli C, Albiez S, Rima L, Righetto R, Mohammed I, Oliva P, et al.
Proc Natl Acad Sci U S A
. 2019 Jul;
116(30):15007-15012.
PMID: 31292253
High-resolution structural information is essential to understand protein function. Protein-structure determination needs a considerable amount of protein, which can be challenging to produce, often involving harsh and lengthy procedures. In...
5.
Schmidli C, Rima L, Arnold S, Stohler T, Syntychaki A, Bieri A, et al.
J Vis Exp
. 2018 Aug;
(137).
PMID: 30102271
Due to recent technological progress, cryo-electron microscopy (cryo-EM) is rapidly becoming a standard method for the structural analysis of protein complexes to atomic resolution. However, protein isolation techniques and sample...
6.
Arnold S, Muller S, Schmidli C, Syntychaki A, Rima L, Chami M, et al.
Proteomics
. 2018 Feb;
18(5-6):e1700176.
PMID: 29441686
This review compares and discusses conventional versus miniaturized specimen preparation methods for transmission electron microscopy (TEM). The progress brought by direct electron detector cameras, software developments and automation have transformed...
7.
Rangl M, Rima L, Klement J, Miyagi A, Keller S, Scheuring S
J Mol Biol
. 2017 Mar;
429(7):977-986.
PMID: 28283404
Phospholipases are abundant in various types of cells and compartments, where they play key roles in physiological processes as diverse as digestion, cell proliferation, and neural activation. In Gram-negative bacteria,...