Luca Iamartino
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Explore the profile of Luca Iamartino including associated specialties, affiliations and a list of published articles.
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9
Citations
69
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Recent Articles
1.
Piatek K, Gushchina V, Kleinwachter A, Kupper N, Mesteri I, Elajnaf T, et al.
Nutrients
. 2025 Jan;
16(24.
PMID: 39770982
Background/objectives: The extracellular calcium-sensing receptor (CaSR) is a multifunctional receptor proposed as a possible drug target for inflammatory bowel disease. We showed previously that CaSR inhibition with NPS 2143, a...
2.
Saffie-Siebert S, Alam I, Sutera F, Dehsorkhi A, Torabi-Pour N, Baran-Rachwalska P, et al.
Calcif Tissue Int
. 2024 May;
115(1):85-96.
PMID: 38733412
Autosomal dominant osteopetrosis type 2 (ADO2) is a rare inherited bone disorder characterised by dense but brittle bones. It displays striking phenotypic variability, with the most severe symptoms, including blindness...
3.
Gushchina V, Kupper N, Schwarzkopf M, Frisch G, Piatek K, Aigner C, et al.
Front Pharmacol
. 2023 May;
14:1151144.
PMID: 37153788
The prostaglandin E (PGE) pathway is one of the main mediators of intestinal inflammation. As activation of the calcium-sensing receptor (CaSR) induces expression of inflammatory markers in the colon, we...
4.
Miglietta F, Iamartino L, Palmini G, Giusti F, Marini F, Iantomasi T, et al.
Front Endocrinol (Lausanne)
. 2023 Jan;
13:1085315.
PMID: 36714597
Hematopoietic stem cell transplantation (HSCT) is an established therapeutic strategy for the treatment of malignant (leukemia and lymphoma) and non-malignant (thalassemia, anemia, and immunodeficiency) hematopoietic diseases. Thanks to the improvement...
5.
Iamartino L, Brandi M
Front Physiol
. 2022 Dec;
13:1059369.
PMID: 36467702
The Calcium-Sensing Receptor (CaSR) is a member of the class C of G-proteins coupled receptors (GPCRs), it plays a pivotal role in calcium homeostasis by directly controlling calcium excretion in...
6.
Schepelmann M, Kupper N, Sladczyk M, Mansfield B, Manhardt T, Piatek K, et al.
Int J Mol Sci
. 2021 Sep;
22(18).
PMID: 34576291
Pharmacological allosteric agonists (calcimimetics) of the extracellular calcium-sensing receptor (CaSR) have substantial gastro-intestinal side effects and induce the expression of inflammatory markers in colon cancer cells. Here, we compared the...
7.
Iamartino L, Elajnaf T, Gall K, David J, Manhardt T, Heffeter P, et al.
Biochim Biophys Acta Mol Cell Res
. 2020 Aug;
1867(12):118836.
PMID: 32861746
The calcium-sensing receptor (CaSR) is a ubiquitously expressed multifunctional G protein-coupled receptor. Several studies reported that the CaSR plays an anti-inflammatory and anti-tumorigenic role in the intestine, and that it...
8.
Elajnaf T, Iamartino L, Mesteri I, Muller C, Bassetto M, Manhardt T, et al.
Nutrients
. 2020 Jan;
11(12).
PMID: 31888253
The calcium-sensing receptor (CaSR) is the main regulator of extracellular Ca homeostasis. It has diverse functions in different tissues, including the intestines. Intestine-specific knockout of the CaSR renders mice more...
9.
Iamartino L, Elajnaf T, Kallay E, Schepelmann M
World J Gastroenterol
. 2018 Oct;
24(36):4119-4131.
PMID: 30271078
The extracellular calcium-sensing receptor (CaSR) is best known for its action in the parathyroid gland and kidneys where it controls body calcium homeostasis. However, the CaSR has different roles in...