Luca Cassetta
Overview
Explore the profile of Luca Cassetta including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
3323
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Recent Articles
1.
Taciak B, Bialasek M, Kubiak M, Marszalek I, Gorczak M, Osadchuk O, et al.
Nat Commun
. 2025 Feb;
16(1):1327.
PMID: 39900573
Treatment of solid tumors remains challenging and therapeutic strategies require continuous development. Tumor-infiltrating macrophages play a pivotal role in tumor dynamics. Here, we present a Macrophage-Drug Conjugate (MDC) platform technology...
2.
Coussens L, de Palma M, Mariani S, Cassetta L
Nat Rev Cancer
. 2023 Jun;
23(8):507.
PMID: 37353680
No abstract available.
3.
Cassetta L, Pollard J
Nat Rev Cancer
. 2023 Feb;
23(4):238-257.
PMID: 36792751
Tumour progression is modulated by the local microenvironment. This environment is populated by many immune cells, of which macrophages are among the most abundant. Clinical correlative data and a plethora...
4.
Robinson A, Burgess M, Webb S, Louwe P, Ouyang Z, Skola D, et al.
Cancers (Basel)
. 2022 Feb;
14(3).
PMID: 35159100
There is a growing body of evidence that cancer causes systemic changes. These influences are most evident in the bone marrow and the blood, particularly in the myeloid compartment. Here,...
5.
Massaiu I, Songia P, Chiesa M, Valerio V, Moschetta D, Alfieri V, et al.
Int J Mol Sci
. 2021 Jul;
22(12).
PMID: 34204756
Transcript sequencing is a crucial tool for gaining a deep understanding of biological processes in diagnostic and clinical medicine. Given their potential to study novel complex eukaryotic transcriptomes, long-read sequencing...
6.
Cassetta L, Bruderek K, Skrzeczynska-Moncznik J, Osiecka O, Hu X, Rundgren I, et al.
J Immunother Cancer
. 2020 Sep;
8(2).
PMID: 32907925
Background: Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that includes myeloid cells with immune suppressive properties. The presence of MDSC has been reported in the peripheral blood...
7.
Lopez-Yrigoyen M, Cassetta L, Pollard J
Ann N Y Acad Sci
. 2020 May;
1499(1):18-41.
PMID: 32445205
Tumorigenesis is not only determined by the intrinsic properties of cancer cells but also by their interactions with components of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are among the...
8.
Lopez-Yrigoyen M, May A, Ventura T, Taylor H, Fidanza A, Cassetta L, et al.
J Vis Exp
. 2020 May;
(158).
PMID: 32364544
Macrophages are present in most vertebrate tissues and comprise widely dispersed and heterogeneous cell populations with different functions. They are key players in health and disease, acting as phagocytes during...
9.
Cassetta L, Pollard J
Curr Biol
. 2020 Mar;
30(6):R246-R248.
PMID: 32208142
Cassetta and Pollard introduce tumor-associated macrophages and discuss their origin, diversity, function and plasticity.
10.
Heideveld E, Horcas-Lopez M, Lopez-Yrigoyen M, Forrester L, Cassetta L, Pollard J
Methods Enzymol
. 2020 Feb;
632:113-131.
PMID: 32000892
Tumor-associated macrophages (TAMs) are becoming a promising target for cancer immunotherapy. Significant efforts have been made to study the detrimental role of TAMs both in vivo and in vitro. However,...