Louis D Van de Kar
Overview
Explore the profile of Louis D Van de Kar including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
605
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Recent Articles
1.
Battaglia G, Cabrera-Vera T, Van de Kar L, Garcia F, Vicentic A, Pinto W
Ann N Y Acad Sci
. 2017 Nov;
846(1):355-357.
PMID: 29087566
No abstract available.
2.
Li Q, Sullivan N, McAllister C, Van de Kar L, Muma N
Psychoneuroendocrinology
. 2012 Dec;
38(7):1145-57.
PMID: 23219224
A major problem with current anti-depressant therapy is that it takes on average 6-7 weeks for remission. Since desensitization of serotonin (5-HT)1A receptor signaling contributes to the anti-depressive response, acceleration...
3.
Crane J, Shimizu K, Carrasco G, Garcia F, Jia C, Sullivan N, et al.
Brain Res
. 2007 Nov;
1183:51-9.
PMID: 17976547
Brain serotonin 1A (5-HT1A) receptors play an important role in mood disorders and can modulate various intracellular signaling mechanisms. We previously reported that systemic administration of either full or partial...
4.
Carrasco G, Van de Kar L, Jia C, Xu H, Chen Z, Chadda R, et al.
J Pharmacol Exp Ther
. 2006 Dec;
320(3):1078-86.
PMID: 17159160
We previously demonstrated colocalization of serotonin 1A (5-HT(1A)) and serotonin 2A (5-HT(2A)) receptors in oxytocin and corticotropin-releasing factor neurons in the hypothalamic paraventricular nucleus (PVN). Because a functional imbalance between...
5.
Shi J, Damjanoska K, Zemaitaitis B, Garcia F, Carrasco G, Sullivan N, et al.
Neuropharmacology
. 2006 Jun;
51(3):524-35.
PMID: 16769091
Serotonin 2A (5-HT2A) receptors are coupled to Galphaq and Galpha11 proteins to activate phospholipase C (PLC). Regulators of G-protein signaling proteins (RGS) modulate G-protein signaling by accelerating the intrinsic GTPase...
6.
Landry M, Frasier M, Chen Z, Van de Kar L, Zhang Y, Garcia F, et al.
Synapse
. 2005 Aug;
58(2):102-9.
PMID: 16088947
Various childhood mood disorders are being treated with serotonin selective reuptake inhibitors (SSRIs) such as fluoxetine (Prozac(R)), yet limited data are available on their effects on serotonergic systems prior to...
7.
Farhadi A, Keshavarzian A, Van de Kar L, Jakate S, Domm A, Zhang L, et al.
Am J Gastroenterol
. 2005 Aug;
100(8):1796-804.
PMID: 16086717
Objectives: Several studies suggest that stressful situations (stressors) worsen the course of inflammatory bowel disease (IBD), but the mechanism is not known. Based on several lines of evidence, we hypothesized...
8.
Chen Z, Tetzlaff J, Sripathirathan K, Carrasco G, Shankaran M, Van de Kar L, et al.
Psychopharmacology (Berl)
. 2005 May;
180(2):316-26.
PMID: 15864558
Rationale: Desensitization of postsynaptic 5-HT(1A) receptors may be responsible for the therapeutic effectiveness of serotonin selective uptake inhibitors (SSRIs). As prenatal cocaine exposure produces long-term deficits in 5-HT neurons in...
9.
Sullivan N, Crane J, Damjanoska K, Carrasco G, DSouza D, Garcia F, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2005 Jan;
371(1):18-26.
PMID: 15655673
Tandospirone, an azapirone, is a selective serotonin(1A) (5-HT(1A)) receptor agonist. The effects of tandospirone on plasma hormones and on mitogen-activated protein (MAP) kinase activity in the brain of male rats...
10.
Grippo A, Sullivan N, Damjanoska K, Crane J, Carrasco G, Shi J, et al.
Psychopharmacology (Berl)
. 2004 Dec;
179(4):769-80.
PMID: 15619113
Rationale: Interactions among stress, serotonin 1A (5-HT(1A)) receptors, and the hypothalamic-pituitary-adrenocortical (HPA) system have been proposed to influence the development of depression in humans. The investigation of depression-relevant behaviors and...