Lori Hazlehurst
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Explore the profile of Lori Hazlehurst including associated specialties, affiliations and a list of published articles.
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19
Citations
295
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Recent Articles
11.
von Roemeling C, Caulfield T, Marlow L, Bok I, Wen J, Miller J, et al.
Oncotarget
. 2018 Feb;
9(1):3-20.
PMID: 29416592
Here we present an innovative computational-based drug discovery strategy, coupled with machine-based learning and functional assessment, for the rational design of novel small molecule inhibitors of the lipogenic enzyme stearoyl-CoA...
12.
Li X, Nelson C, Nair R, Hazlehurst L, Moroni T, Martinez-Acedo P, et al.
Cell Chem Biol
. 2017 Mar;
24(4):433-442.e6.
PMID: 28330604
Selenomabs are engineered monoclonal antibodies with one or more translationally incorporated selenocysteine residues. The unique reactivity of the selenol group of selenocysteine permits site-specific conjugation of drugs. Compared with other...
13.
Khin Z, Ribeiro M, Jacobson T, Hazlehurst L, Perez L, Baz R, et al.
Cancer Res
. 2013 Dec;
74(1):56-67.
PMID: 24310398
Accurate preclinical predictions of the clinical efficacy of experimental cancer drugs are highly desired but often haphazard. Such predictions might be improved by incorporating elements of the tumor microenvironment in...
14.
Xiang Y, Remily-Wood E, Oliveira V, Yarde D, He L, Cheng J, et al.
Mol Cell Proteomics
. 2011 Aug;
10(11):M110.005520.
PMID: 21846842
The emergence of acquired drug resistance results from multiple compensatory mechanisms acting to prevent cell death. Simultaneous monitoring of proteins involved in drug resistance is a major challenge for both...
15.
Remily-Wood E, Liu R, Xiang Y, Chen Y, Thomas C, Rajyaguru N, et al.
Proteomics Clin Appl
. 2011 Jun;
5(7-8):383-96.
PMID: 21656910
Purpose: The Quantitative Assay Database (QuAD), http://proteome.moffitt.org/QUAD/, facilitates widespread implementation of quantitative mass spectrometry in cancer biology and clinical research through sharing of methods and reagents for monitoring protein expression...
16.
Kamath V, Goldgof D, Argilagos R, Hazlehurst L, Eschrich S
Annu Int Conf IEEE Eng Med Biol Soc
. 2009 Jan;
2008:3079-82.
PMID: 19163357
Biophotonic imaging can be used to characterize tumor growth in animal models. Estimation of the numbers and location of target cells is dependent on accurate segmentation of a target region...
17.
Turner J, Gump J, Zhang C, Cook J, Marchion D, Hazlehurst L, et al.
Blood
. 2006 Aug;
108(12):3881-9.
PMID: 16917002
We investigated the role of the breast cancer resistance protein (BCRP/ABCG2) in drug resistance in multiple myeloma (MM). Human MM cell lines, and MM patient plasma cells isolated from bone...
18.
Dalton W, Hazlehurst L, Shain K, Landowski T, Alsina M
Semin Hematol
. 2004 Jun;
41(2 Suppl 4):1-5.
PMID: 15190509
Unicellular drug-resistant models have been critical in elucidating intrinsic drug-resistant mechanisms; however, these models do not consider resistance mechanisms that may be elicited by extrinsic influences such as the tumor...
19.
Engel R, Valkov N, Gump J, Hazlehurst L, Dalton W, Sullivan D
Exp Cell Res
. 2004 Apr;
295(2):421-31.
PMID: 15093741
In this study we have investigated the role of topoisomerase (topo) IIalpha trafficking in cellular drug resistance. To accomplish this, it was necessary to separate the influence of cell cycle,...
20.
Anderson K, Kyle R, Dalton W, Landowski T, Shain K, Jove R, et al.
Hematology Am Soc Hematol Educ Program
. 2001 Nov;
:147-165.
PMID: 11701540
This review discusses the evolution of novel diagnostic and treatment strategies for multiple myeloma based upon increased understanding of basic disease pathogenesis. Although myeloma has remained an incurable illness to...