Lorenzo Scipioni
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Explore the profile of Lorenzo Scipioni including associated specialties, affiliations and a list of published articles.
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25
Citations
304
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Recent Articles
11.
Agustinus A, Al-Rawi D, Dameracharla B, Raviram R, Jones B, Stransky S, et al.
Nature
. 2023 Jun;
619(7968):176-183.
PMID: 37286593
Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers, but whether they are mechanistically linked is unknown. Here we show that missegregation of mitotic chromosomes, their...
12.
Fazel M, Vallmitjana A, Scipioni L, Gratton E, Digman M, Presse S
Biophys J
. 2023 Jan;
122(4):672-683.
PMID: 36659850
Fluorescence lifetime imaging captures the spatial distribution of chemical species across cellular environments employing pulsed illumination confocal setups. However, quantitative interpretation of lifetime data continues to face critical challenges. For...
13.
Halbrook C, Thurston G, Boyer S, Anaraki C, Jimenez J, McCarthy A, et al.
Nat Cancer
. 2022 Nov;
3(11):1386-1403.
PMID: 36411320
The pancreatic tumor microenvironment drives deregulated nutrient availability. Accordingly, pancreatic cancer cells require metabolic adaptations to survive and proliferate. Pancreatic cancer subtypes have been characterized by transcriptional and functional differences,...
14.
Fazel M, Jazani S, Scipioni L, Vallmitjana A, Gratton E, Digman M, et al.
ACS Photonics
. 2022 Jul;
9(3):1015-1025.
PMID: 35847830
Fluorescence lifetime imaging microscopy (FLIM) may reveal subcellular spatial lifetime maps of key molecular species. Yet, such a quantitative picture of life necessarily demands high photon budgets at every pixel...
15.
Yao Z, Brennan C, Scipioni L, Chen H, Ng K, Tedeschi G, et al.
Nat Methods
. 2022 Jun;
19(7):893-898.
PMID: 35739310
Bioluminescence imaging with luciferase-luciferin pairs is a well-established technique for visualizing biological processes across tissues and whole organisms. Applications at the microscale, by contrast, have been hindered by a lack...
16.
Solano A, Lou J, Scipioni L, Gratton E, Hinde E
Biophys J
. 2022 May;
121(11):2152-2167.
PMID: 35490296
Nuclear proteins can modulate their DNA binding activity and the exploration volume available during DNA target search by self-associating into higher-order oligomers. Directly tracking this process in the nucleoplasm of...
17.
Tedeschi G, Scipioni L, Papanikolaou M, Abbott G, Digman M
Sci Rep
. 2021 May;
11(1):10719.
PMID: 34021177
Voltage-gated potassium (Kv) channels are a family of membrane proteins that facilitate K ion diffusion across the plasma membrane, regulating both resting and action potentials. Kv channels comprise four pore-forming...
18.
Scipioni L, Rossetta A, Tedeschi G, Gratton E
Nat Methods
. 2021 Apr;
18(5):542-550.
PMID: 33859440
Fluorescence lifetime imaging microscopy (FLIM) and spectral imaging are two broadly applied methods for increasing dimensionality in microscopy. However, their combination is typically inefficient and slow in terms of acquisition...
19.
Liang Z, Lou J, Scipioni L, Gratton E, Hinde E
Data Brief
. 2020 Apr;
30:105401.
PMID: 32300614
The nanometer spacing between nucleosomes throughout global chromatin organisation modulates local DNA template access, and through continuous dynamic rearrangements, regulates genome function [1]. However, given that nucleosome packaging occurs on...
20.
Oneto M, Scipioni L, Sarmento M, Cainero I, Pelicci S, Furia L, et al.
Biophys J
. 2019 Nov;
117(11):2054-2065.
PMID: 31732142
Deciphering the spatiotemporal coordination between nuclear functions is important to understand its role in the maintenance of human genome. In this context, super-resolution microscopy has gained considerable interest because it...