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Lorenzo Benatuil

Explore the profile of Lorenzo Benatuil including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 295
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Recent Articles
1.
Sun V, Melim T, Mitra S, Erickson J, Bryant S, Farnham A, et al.
Adv Rheumatol . 2022 May; 62(1):17. PMID: 35624488
Objectives: To assess the ability of monoclonal antibodies (mAbs) specific for fibronectin extra-domain A (FnEDA) to target diseased tissues of mouse collagen induced arthritis (mCIA) models. To explore the parameters...
2.
Argiriadi M, Benatuil L, Dubrovska I, Egan D, Gao L, Greischar A, et al.
BMC Mol Cell Biol . 2019 Aug; 20(1):29. PMID: 31382872
Background: CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L...
3.
Phillips A, Boghaert E, Vaidya K, Falls H, Mitten M, DeVries P, et al.
Mol Cancer Ther . 2018 Feb; 17(4):795-805. PMID: 29483208
Depatuxizumab mafodotin (depatux-m, ABT-414) is a tumor-selective antibody drug conjugate (ADC) comprised of the anti-EGFR antibody ABT-806 and the monomethyl auristatin F (MMAF) warhead. Depatux-m has demonstrated promising clinical activity...
4.
Chen L, Duan Y, Benatuil L, Stine W
Protein Eng Des Sel . 2017 May; 30(9):603-609. PMID: 28472386
Clear and accurate understanding of diversity in antibody complementarity-determining regions (CDRs) is critical for antibody discovery and engineering. Previous observations of antibody CDR-H3 diversity were based on analyzing available antibody...
5.
Ding K, Eaton L, Bowley D, Rieser M, Chang Q, Harris M, et al.
MAbs . 2016 Dec; 9(2):269-284. PMID: 27929753
Exudative age-related macular degeneration (AMD) is the most common cause of moderate and severe vision loss in developed countries. Intraocular injections of vascular endothelial growth factor (VEGF or VEGF-A)-neutralizing proteins...
6.
Benatuil L, Perez J, Belk J, Hsieh C
Protein Eng Des Sel . 2010 Feb; 23(4):155-9. PMID: 20130105
Antibody library selection by yeast display technology is an efficient and highly sensitive method to identify binders to target antigens. This powerful selection tool, however, is often hampered by the...
7.
Benatuil L, Kaye J, Cretin N, Godwin J, Cariappa A, Pillai S, et al.
J Immunol . 2008 Mar; 180(6):3839-48. PMID: 18322191
Natural Abs specific for the carbohydrate Ag Galalpha1-3Galbeta1-4GlcNAc-R (alphaGal) play an important role in providing protective host immunity to various pathogens; yet little is known about how production of these...
8.
Paez J, Montano R, Benatuil L, Iacomini J, Cardier J
Endothelium . 2006 Sep; 13(4):279-85. PMID: 16990184
The liver sinusoidal endothelial cells (LSECs) constitute a very specialized endothelium. Due to their multiple functions and privileged location in the liver, these cells constitute an excellent target for gene...
9.
Benatuil L, Kaye J, Rich R, Fishman J, Green W, Iacomini J
Eur J Immunol . 2005 Aug; 35(9):2638-47. PMID: 16082726
The natural antibody repertoire in humans, apes and Old World primates is distinct from the repertoire of all other placental mammals, and encodes antibodies specific for the carbohydrate epitope Galalpha1-3Galbeta1-4GlcNAc-R...
10.
Benatuil L, Fernandez A, Romano E
Xenotransplantation . 2003 Sep; 10(5):454-9. PMID: 12950988
The infusion of pig progenitor cells into baboons is associated with a thrombotic microangiopathy probably related to the interaction of these cells with the baboon endothelial cells and platelets. We...