Lorena Aguilar-Arnal
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Explore the profile of Lorena Aguilar-Arnal including associated specialties, affiliations and a list of published articles.
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23
Citations
487
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Recent Articles
11.
Nunez-Olvera S, Puente-Rivera J, Ramos-Payan R, Perez-Plasencia C, Salinas-Vera Y, Aguilar-Arnal L, et al.
Cells
. 2022 Jan;
11(1).
PMID: 35011637
A growing body of research on the transcriptome and cancer genome has demonstrated that many gynecological tumor-specific gene mutations are located in cis-regulatory elements. Through chromosomal looping, cis-regulatory elements interact...
12.
Orozco-Solis R, Aguilar-Arnal L
Front Cell Infect Microbiol
. 2020 Apr;
10:96.
PMID: 32232012
The circadian clock orchestrates daily rhythms in many physiological, behavioral and molecular processes, providing means to anticipate, and adapt to environmental changes. A specific role of the circadian clock is...
13.
Pacheco-Bernal I, Becerril-Perez F, Aguilar-Arnal L
Clin Epigenetics
. 2019 May;
11(1):79.
PMID: 31092281
Circadian rhythms orchestrate crucial physiological functions and behavioral aspects around a day in almost all living forms. The circadian clock is a time tracking system that permits organisms to predict...
14.
Orozco-Solis R, Montellier E, Aguilar-Arnal L, Sato S, Vawter M, Bunney B, et al.
Biol Psychiatry
. 2017 Apr;
82(5):351-360.
PMID: 28395871
Background: Conventional antidepressants usually require several weeks to achieve a full clinical response in patients with major depressive disorder, an illness associated with dysregulated circadian rhythms and a high incidence...
15.
Aguilar-Arnal L, Ranjit S, Stringari C, Orozco-Solis R, Gratton E, Sassone-Corsi P
Proc Natl Acad Sci U S A
. 2016 Oct;
113(45):12715-12720.
PMID: 27791113
Sirtuin 1 (SIRT1) is an NAD-dependent deacetylase that functions as metabolic sensor of cellular energy and modulates biochemical pathways in the adaptation to changes in the environment. SIRT1 substrates include...
16.
Daulny A, Mejia-Ramirez E, Reina O, Rosado-Lugo J, Aguilar-Arnal L, Auer H, et al.
Biochim Biophys Acta
. 2016 Jun;
1859(10):1314-21.
PMID: 27345571
It is well established that eukaryotic genomes are pervasively transcribed producing cryptic unstable transcripts (CUTs). However, the mechanisms regulating pervasive transcription are not well understood. Here, we report that the...
17.
Aguilar-Arnal L, Sassone-Corsi P
Curr Mol Biol Rep
. 2016 Mar;
1(1):1-9.
PMID: 27014564
The molecular circadian clock orchestrates the daily cyclical expression of thousands of genes. Disruption of this transcriptional program leads to a variety of pathologies, including insomnia, depression and metabolic disorders....
18.
Orozco-Solis R, Aguilar-Arnal L, Murakami M, Peruquetti R, Ramadori G, Coppari R, et al.
Cell Metab
. 2016 Mar;
23(3):467-78.
PMID: 26959185
Organismal homeostasis relies on coherent interactions among tissues, specifically between brain-driven functions and peripheral metabolic organs. Hypothalamic circuits compute metabolic information to optimize energetic resources, but the role of the...
19.
Aguilar-Arnal L, Katada S, Orozco-Solis R, Sassone-Corsi P
Nat Struct Mol Biol
. 2015 Mar;
22(4):312-8.
PMID: 25751424
The circadian clock controls the transcription of hundreds of genes through specific chromatin-remodeling events. The histone methyltransferase mixed-lineage leukemia 1 (MLL1) coordinates recruitment of CLOCK-BMAL1 activator complexes to chromatin, an...
20.
Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription
Aguilar-Arnal L, Sassone-Corsi P
Proc Natl Acad Sci U S A
. 2014 Nov;
112(22):6863-70.
PMID: 25378702
Circadian rhythms drive the temporal organization of a wide variety of physiological and behavioral functions in ∼24-h cycles. This control is achieved through a complex program of gene expression. In...