Loren P Thompson
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Explore the profile of Loren P Thompson including associated specialties, affiliations and a list of published articles.
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27
Citations
497
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Recent Articles
1.
Thompson L, Song H, Hartnett J
Reprod Sci
. 2023 Nov;
31(4):975-986.
PMID: 37957471
Gestational hypoxia inhibits mitochondrial function in the fetal heart and placenta contributing to fetal growth restriction and organ dysfunction. NAD + deficiency may contribute to a metabolic deficit by inhibiting...
2.
Song H, Thompson L
Reprod Sci
. 2023 May;
30(10):2996-3009.
PMID: 37138147
Chronic intrauterine hypoxia is a significant pregnancy complication impacting fetal heart growth, metabolism, and mitochondrial function, contributing to cardiovascular programming of the offspring. PGC1α (peroxisome proliferator-activated receptor γ co-activator 1α)...
3.
Elsamadicy E, Thompson L
Reprod Sci
. 2022 May;
29(10):3015-3025.
PMID: 35616874
Chronic hypoxia can cause fetal growth restriction (FGR) through placental dysfunction. Insulin-like growth factors (IGFs), such as IGF-2, play a major role in preservation of placental growth and function. We...
4.
Quebedeaux T, Song H, Giwa-Otusajo J, Thompson L
Reprod Sci
. 2021 Nov;
29(1):184-192.
PMID: 34750769
Mitochondrial dysfunction is an underlying cause of childhood neurological disease secondary to the crucial role of mitochondria in proper neurodevelopment. We hypothesized that chronic intrauterine hypoxia (HPX) induces mitochondrial deficits...
5.
Song H, Polster B, Thompson L
Am J Physiol Regul Integr Comp Physiol
. 2021 Nov;
321(6):R912-R924.
PMID: 34730023
We hypothesize that intrauterine hypoxia (HPX) alters the mitochondrial phenotype in fetal hearts contributing to developmental programming. Pregnant guinea pigs were exposed to normoxia (NMX) or hypoxia (HPX, 10.5% O),...
6.
Thompson L, Turan S, Aberdeen G
Am J Physiol Regul Integr Comp Physiol
. 2020 Jul;
319(3):R243-R254.
PMID: 32639864
We hypothesized that the physiological adaptations of the fetus in response to chronic intrauterine hypoxia depend on its sex and the gestational age of exposure. Pregnant guinea pigs were exposed...
7.
Thompson L, Song H, Polster B
Oxid Med Cell Longev
. 2019 Jun;
2019:7210249.
PMID: 31249648
Chronic intrauterine hypoxia is a programming stimulus of cardiovascular dysfunction. While the fetal heart adapts to the reduced oxygenation, the offspring heart becomes vulnerable to subsequent metabolic challenges as an...
8.
Thompson L, Chen L, Polster B, Pinkas G, Song H
Am J Physiol Regul Integr Comp Physiol
. 2018 Oct;
315(6):R1232-R1241.
PMID: 30365351
Adverse intrauterine conditions cause fetal growth restriction and increase the risk of adult cardiovascular disease. We hypothesize that intrauterine hypoxia impairs fetal heart function, is sustained after birth, and manifests...
9.
Song H, Telugu B, Thompson L
Biol Reprod
. 2018 Aug;
100(1):208-216.
PMID: 30085007
Placental hypoxia can stimulate oxidative stress and mitochondrial dysfunction reducing placental efficiency and inducing fetal growth restriction (FGR). We hypothesized that chronic hypoxia inhibits mitochondrial function in the placenta as...
10.
Morrison J, Botting K, Darby J, David A, Dyson R, Gatford K, et al.
J Physiol
. 2018 Apr;
596(23):5535-5569.
PMID: 29633280
Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual's risk of non-communicable disease in later life: the developmental origins...