Lorcan Browne
Overview
Explore the profile of Lorcan Browne including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
159
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0
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Recent Articles
1.
Ellingford R, Panasiuk M, de Meritens E, Shaunak R, Naybour L, Browne L, et al.
Mol Psychiatry
. 2021 Apr;
26(7):3614-3624.
PMID: 33837267
Heterozygous mutation of chromodomain helicase DNA binding protein 8 (CHD8) is strongly associated with autism spectrum disorder (ASD) and results in dysregulated expression of neurodevelopmental and synaptic genes during brain...
2.
Lipovsek M, Browne L, Grubb M
STAR Protoc
. 2020 Dec;
1(3):100146.
PMID: 33377040
Obtaining electrophysiological recordings and gene expression information from the same neuron (Patch-seq) brings forward a unique opportunity to study the transcriptional correlates of functional properties and vice versa. Here, we...
3.
Mager T, Lopez de la Morena D, Senn V, Schlotte J, D Errico A, Feldbauer K, et al.
Nat Commun
. 2018 May;
9(1):1750.
PMID: 29717130
Optogenetics revolutionizes basic research in neuroscience and cell biology and bears potential for medical applications. We develop mutants leading to a unifying concept for the construction of various channelrhodopsins with...
4.
Browne L, Smith K, Jagger D
eNeuro
. 2017 Nov;
4(6).
PMID: 29138759
In spiral ganglion neurons (SGNs), the afferent single units of the auditory nerve, high spontaneous and evoked firing rates ensure preservation of the temporal code describing the key features of...
5.
Smith K, Browne L, Selwood D, McAlpine D, Jagger D
J Neurosci
. 2015 Aug;
35(32):11221-32.
PMID: 26269632
Significance Statement: Rapid spike adaptation is an important feature of auditory neurons that preserves temporal precision. In spiral ganglion neurons, the primary afferents in the cochlea, adaptation is regulated by...
6.
Browne L, Lidster K, Al-Izki S, Clutterbuck L, Posada C, Chan A, et al.
J Med Chem
. 2015 Apr;
58(8):3637.
PMID: 25849447
No abstract available.
7.
Browne L, Lidster K, Al-Izki S, Clutterbuck L, Posada C, Chan A, et al.
J Med Chem
. 2014 Mar;
57(7):2942-52.
PMID: 24601592
A series of imidazol-1-ylethylindazole sodium channel ligands were developed and optimized for sodium channel inhibition and in vitro neuroprotective activity. The molecules exhibited displacement of a radiolabeled sodium channel ligand...
8.
Al-Izki S, Pryce G, Hankey D, Lidster K, von Kutzleben S, Browne L, et al.
Brain
. 2013 Nov;
137(Pt 1):92-108.
PMID: 24287115
Progressive multiple sclerosis is associated with metabolic failure of the axon and excitotoxicity that leads to chronic neurodegeneration. Global sodium-channel blockade causes side effects that can limit its use for...