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Logeshwaran Somasundaram

Explore the profile of Logeshwaran Somasundaram including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 115
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Recent Articles
1.
Levy S, Somasundaram L, Xavier Raj I, Ic-Mex D, Phal A, Schmidt S, et al.
Cell Rep . 2022 Mar; 38(9):110457. PMID: 35235780
Bifurcation of cellular fates, a critical process in development, requires histone 3 lysine 27 methylation (H3K27me3) marks propagated by the polycomb repressive complex 2 (PRC2). However, precise chromatin loci of...
2.
Zhao Y, Fallas J, Saini S, Ueda G, Somasundaram L, Zhou Z, et al.
EMBO Rep . 2021 Oct; 22(12):e53471. PMID: 34698433
Angiopoietins 1 and 2 (Ang1 and Ang2) regulate angiogenesis through their similar F-domains by activating Tie2 receptors on endothelial cells. Despite the similarity in the underlying receptor-binding interaction, the two...
3.
Ben-Sasson A, Watson J, Sheffler W, Johnson M, Bittleston A, Somasundaram L, et al.
Nature . 2021 Mar; 591(7850):E16. PMID: 33654323
No abstract available.
4.
Zhao Y, Fallas J, Saini S, Ueda G, Somasundaram L, Zhou Z, et al.
bioRxiv . 2021 Jan; PMID: 33501432
Angiopoietin 1 and 2 (Ang1 and Ang2) modulate angiogenesis and vascular homeostasis through engagement of their very similar F-domain modules with the Tie2 receptor tyrosine kinase on endothelial cells. Despite...
5.
Ben-Sasson A, Watson J, Sheffler W, Johnson M, Bittleston A, Somasundaram L, et al.
Nature . 2021 Jan; 589(7842):468-473. PMID: 33408408
Ordered two-dimensional arrays such as S-layers and designed analogues have intrigued bioengineers, but with the exception of a single lattice formed with flexible linkers, they are constituted from just one...
6.
Somasundaram L, Levy S, Hussein A, Ehnes D, Mathieu J, Ruohola-Baker H
Curr Top Dev Biol . 2020 Mar; 138:209-240. PMID: 32220298
It has become clear during recent years that stem cells undergo metabolic remodeling during their activation process. While these metabolic switches take place in pluripotency as well as adult stem...
7.
Wang Y, Hussein A, Somasundaram L, Sankar R, Detraux D, Mathieu J, et al.
Int J Mol Sci . 2019 Nov; 20(23). PMID: 31766734
microRNAs are ~22bp nucleotide non-coding RNAs that play important roles in the post-transcriptional regulation of gene expression. Many studies have established that microRNAs are important for cell fate choices, including...
8.
Ferreccio A, Mathieu J, Detraux D, Somasundaram L, Cavanaugh C, Sopher B, et al.
Cell Cycle . 2018 Feb; 17(5):535-549. PMID: 29466914
To easily edit the genome of naïve human embryonic stem cells (hESC), we introduced a dual cassette encoding an inducible Cas9 into the AAVS1 site of naïve hESC (iCas9). The...