Lizhe Zhu
Overview
Explore the profile of Lizhe Zhu including associated specialties, affiliations and a list of published articles.
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Articles
72
Citations
1004
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Recent Articles
1.
Xi K, Liu J, Zhu L
J Chem Inf Model
. 2025 Mar;
PMID: 40064618
Locating the low free energy paths (LFEPs) connecting different conformational states is among the major tasks for the simulations of complex biomolecules as the pathways encode the physical essence and,...
2.
Ye Q, Ma J, Wang Z, Liu T, Wang B, Zhu L, et al.
Nat Commun
. 2024 Dec;
15(1):10596.
PMID: 39632881
53BP1 plays an important role in DNA double-strand break (DSB) repair and this activity is negatively regulated by its interaction with Tudor interacting repair regulator (TIRR). However, how the TIRR-53BP1...
3.
Liu J, Zhu L
Molecules
. 2024 Nov;
29(21).
PMID: 39519677
CRISPR-Cas12e is a recently identified gene-editing tool mainly known because its relatively small size benefits cell delivery. Drastically different from Cas9, it creates a blunt-end double-strand breakage of the DNA...
4.
Liu A, Liu Y, Chen G, Lyu W, Ye F, Wang J, et al.
PLoS Biol
. 2024 Oct;
22(10):e3002838.
PMID: 39466725
Chemerin is an adipokine with chemotactic activity to a subset of leukocytes. Chemerin binds to 3 G protein-coupled receptors, including chemokine-like receptor 1 (CMKLR1), G protein-coupled receptor 1 (GPR1), and...
5.
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, et al.
Cell Rep
. 2024 Oct;
43(11):114895.
PMID: 39427321
Hydroxycarboxylic acid receptor 3 (HCAR3), a class A G-protein-coupled receptor, is an important cellular energy metabolism sensor with a key role in the regulation of lipolysis in humans. HCAR3 is...
6.
Halder R, Chu Z, Ti R, Zhu L, Warshel A
J Am Chem Soc
. 2024 Oct;
PMID: 39367841
The origin of the unique directionality of myosin has been a problem of fundamental and practical importance. This work establishes in a conclusive way that the directionality is controlled by...
7.
Wang Y, Dahmane S, Ti R, Mai X, Zhu L, Carlson L, et al.
Nat Struct Mol Biol
. 2024 Aug;
32(1):35-47.
PMID: 39174844
Autophagy is characterized by the formation of double-membrane vesicles called autophagosomes. Autophagy-related proteins (ATGs) 2A and 9A have an essential role in autophagy by mediating lipid transfer and re-equilibration between...
8.
Liu Y, Liu A, Li X, Liao Q, Zhang W, Zhu L, et al.
Cell Rep
. 2024 Aug;
43(8):114578.
PMID: 39093700
CXCR4 binding of its endogenous agonist CXCL12 leads to diverse functions, including bone marrow retention of hematopoietic progenitors and cancer metastasis. However, the structure of the CXCL12-bound CXCR4 remains unresolved...
9.
Ti R, Pang B, Yu L, Gan B, Ma W, Warshel A, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(8):e2317893121.
PMID: 38346183
Physics-based simulation methods can grant atomistic insights into the molecular origin of the function of biomolecules. However, the potential of such approaches has been hindered by their low efficiency, including...
10.
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, et al.
Cell Discov
. 2023 Nov;
9(1):118.
PMID: 38012147
Hydroxycarboxylic acid receptor 2 (HCAR2) belongs to the family of class A G protein-coupled receptors with key roles in regulating lipolysis and free fatty acid formation in humans. It is...