Liton Kumar Saha
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Explore the profile of Liton Kumar Saha including associated specialties, affiliations and a list of published articles.
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21
Citations
334
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Recent Articles
1.
Khandagale P, Sun Y, Saha S, Saha L, Pommier Y
bioRxiv
. 2025 Jan;
PMID: 39803571
Alternative Lengthening of Telomeres (ALT) is a homologous recombination-dependent telomere elongation mechanism utilized by at least 10-15% of all cancers. Here we identified that the DNA topoisomerase, TOP3A is enriched...
2.
Sun Y, Jenkins L, El Touny L, Zhu L, Yang X, Jo U, et al.
Sci Adv
. 2025 Jan;
11(2):eads2919.
PMID: 39792662
DNA-protein cross-links (DPCs) are among the most detrimental genomic lesions. They are ubiquitously produced by formaldehyde (FA), and failure to repair FA-induced DPCs blocks chromatin-based processes, leading to neurodegeneration and...
3.
Mizunuma M, Redon C, Saha L, Tran A, Dhall A, Sebastian R, et al.
Cancer Res Commun
. 2024 Jul;
4(8):2101-2111.
PMID: 39041239
Significance: Acetalax and bisacodyl kill cancer cells by causing oncosis following poisoning of the plasma membrane sodium transporter TRPM4 and represent a new therapeutic approach for TNBC.
4.
Saha L, Sun Y, Saha S, Yang X, Pommier Y
Cell Rep
. 2024 Jul;
43(8):114522.
PMID: 39028621
Persistent DNA-protein crosslinks formed by human topoisomerase IIIα (TOP3A-DPCs) interfere with DNA metabolism and lead to genome damage and cell death. Recently, we demonstrated that such abortive TOP3A-DPCs are ubiquitylated...
5.
Zhang H, Sun Y, Saha S, Saha L, Pongor L, Dhall A, et al.
bioRxiv
. 2024 Jul;
PMID: 38948815
Both transcription and replication can take place simultaneously on the same DNA template, potentially leading to transcription-replication conflicts (TRCs) and topological problems. Here we asked which topoisomerase(s) is/are the best...
6.
Schultz C, Zhang Y, Elmeskini R, Zimmermann A, Fu H, Murai Y, et al.
EMBO Mol Med
. 2024 Feb;
16(3):664.
PMID: 38366163
No abstract available.
7.
Saha L, Pommier Y
Cell Cycle
. 2024 Feb;
23(2):115-130.
PMID: 38341866
Humans have two Type IA topoisomerases, topoisomerase IIIα (TOP3A) and topoisomerase IIIβ (TOP3B). In this review, we focus on the role of human TOP3A in DNA replication and highlight the...
8.
Saha S, Huang S, Yang X, Saha L, Sun Y, Khandagale P, et al.
Nat Commun
. 2023 Nov;
14(1):7524.
PMID: 37980342
TOP3B is stabilized by TDRD3. Hypothesizing that TDRD3 recruits a deubiquitinase, we find that TOP3B interacts with USP9X via TDRD3. Inactivation of USP9X destabilizes TOP3B, and depletion of both TDRD3...
9.
Schultz C, Zhang Y, Elmeskini R, Zimmermann A, Fu H, Murai Y, et al.
EMBO Mol Med
. 2023 Jul;
15(8):e17313.
PMID: 37491889
Small-cell lung cancer (SCLC) is the most lethal type of lung cancer. Specifically, MYC-driven non-neuroendocrine SCLC is particularly resistant to standard therapies. Lurbinectedin was recently approved for the treatment of...
10.
Saha L, Saha S, Yang X, Huang S, Sun Y, Jo U, et al.
Nat Commun
. 2023 Apr;
14(1):1925.
PMID: 37024461
Topoisomerase IIIα (TOP3A) belongs to the conserved Type IA family of DNA topoisomerases. Here we report that human TOP3A is associated with DNA replication forks and that a "self-trapping" TOP3A...