Lisha Joshi
Overview
Explore the profile of Lisha Joshi including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
159
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Recent Articles
1.
Talbot E, Joshi L, Thornton P, Dezfouli M, Tsafou K, Perkinton M, et al.
Nucleic Acids Res
. 2023 Dec;
52(3):1188-1206.
PMID: 38084916
Defective DNA damage signalling and repair is a hallmark of age-related and genetic neurodegenerative disease. One mechanism implicated in disease progression is DNA damage-driven neuroinflammation, which is largely mediated by...
2.
Joshi L, Plastira I, Bernhart E, Reicher H, Koshenov Z, Graier W, et al.
Cells
. 2022 Apr;
11(7).
PMID: 35406635
Systemic inflammation induces alterations in the finely tuned micromilieu of the brain that is continuously monitored by microglia. In the CNS, these changes include increased synthesis of the bioactive lipid...
3.
Joshi L, Plastira I, Bernhart E, Reicher H, Triebl A, Kofeler H, et al.
Int J Mol Sci
. 2021 Aug;
22(16).
PMID: 34445223
Increasing evidence suggests that systemic inflammation triggers a neuroinflammatory response that involves sustained microglia activation. This response has deleterious consequences on memory and learning capability in experimental animal models and...
4.
Guillot-Sestier M, Araiz A, Mela V, Gaban A, ONeill E, Joshi L, et al.
Commun Biol
. 2021 Jun;
4(1):711.
PMID: 34112929
Age and sex are major risk factors in Alzheimer's disease (AD) with a higher incidence of the disease in females. Neuroinflammation, which is a hallmark of AD, contributes to disease...
5.
Joshi L, Plastira I, Bernhart E, Reicher H, Koyani C, Madl T, et al.
Int J Mol Sci
. 2021 Mar;
22(4).
PMID: 33671212
Lysophosphatidic acid (LPA) species are a family of bioactive lipids that transmit signals via six cognate G protein-coupled receptors, which are required for brain development and function of the nervous...
6.
Plastira I, Bernhart E, Joshi L, Koyani C, Strohmaier H, Reicher H, et al.
J Neuroinflammation
. 2020 Apr;
17(1):127.
PMID: 32326963
Background: In the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors. Members of the LPA family are potent lipid mediators transmitting signals via...
7.
Plastira I, Joshi L, Bernhart E, Schoene J, Specker E, Nazare M, et al.
Front Cell Neurosci
. 2019 Dec;
13:531.
PMID: 31849616
Lysophosphatidic acid (LPA) species in the extracellular environment induce downstream signaling six different G protein-coupled receptors (LPAR1-6). These signaling cascades are essential for normal brain development and function of the...