Lisa S McCoy
Overview
Explore the profile of Lisa S McCoy including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
8
Citations
136
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Hamill K, McCoy L, Wexselblatt E, Esko J, Tor Y
Chem Sci
. 2017 Jan;
7(8):5059-5068.
PMID: 28044098
Polymyxin B is an antibiotic used against multi-resistant gram negative infections, despite observed nephrotoxicity. Here we report the synthesis of functionalized derivatives of polymyxin B and its per-guanidinylated derivative in...
2.
Hopkins P, McCoy L, Tor Y
Org Biomol Chem
. 2016 Dec;
15(3):684-690.
PMID: 27981333
To display favorable fluorescent properties, the non-emissive native nucleosides need to be modified. Here we present a motif that relies on conjugating 5-membered aromatic heterocycles (e.g., thiophene) to a 6-azapyrimidine...
3.
McCoy L, Shin D, Tor Y
J Am Chem Soc
. 2014 Sep;
136(43):15176-84.
PMID: 25255464
The fastidious behavior of T7 RNA polymerase limits the incorporation of synthetic nucleosides into RNA transcripts, particularly at or near the promoter. The practically exclusive use of GTP for transcription...
4.
Xu L, Chen Y, Chong J, Fin A, McCoy L, Xu J, et al.
Angew Chem Int Ed Engl
. 2014 Aug;
53(42):11223-7.
PMID: 25159856
Methylcytosine (5mC) is mostly symmetrically distributed in CpG sites. Ten-eleven-translocation (TET) proteins are the key enzymes involved in active DNA demethylation through stepwise oxidation of 5mC. However, oxidation pathways of...
5.
Fair R, McCoy L, Hensler M, Aguilar B, Nizet V, Tor Y
ChemMedChem
. 2014 Jul;
9(9):2164-71.
PMID: 25055981
Semisynthetic derivatives of the clinically useful aminoglycosides tobramycin and amikacin were prepared by selectively modifying their 6'' positions with a variety of hydrogen bond donors and acceptors. Their binding to...
6.
Sinkeldam R, McCoy L, Shin D, Tor Y
Angew Chem Int Ed Engl
. 2013 Nov;
52(52):14026-30.
PMID: 24288262
No abstract available.
7.
McCoy L, Roberts K, Nation R, Thompson P, Velkov T, Li J, et al.
Chembiochem
. 2013 Oct;
14(16):2083-6.
PMID: 24105917
Looking for targets: while the bactericidal activity of polymyxins is attributed to changes in membrane permeation, we show that these antibiotics can bind prokaryotic and eukaryotic A-sites, domains responsible for...
8.
McCoy L, Xie Y, Tor Y
Wiley Interdiscip Rev RNA
. 2011 Sep;
2(2):209-32.
PMID: 21957007
The key role of the bacterial ribosome makes it an important target for antibacterial agents. Indeed, a large number of clinically useful antibiotics target this complex translational ribonucleoprotein machinery. The...