Linh M Vuong
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Explore the profile of Linh M Vuong including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
122
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Recent Articles
1.
Brindani N, Vuong L, La Serra M, Salvador N, Menichetti A, Acquistapace I, et al.
J Med Chem
. 2024 Jun;
67(12):10401-10424.
PMID: 38866385
We previously reported trisubstituted pyrimidine lead compounds, namely, ARN22089 and ARN25062, which block the interaction between CDC42 with its specific downstream effector, a PAK protein. This interaction is crucial for...
2.
Vuong L, Pan S, Sierra R, Waterman M, Gershon P, Donovan P
Proteomics
. 2024 Apr;
24(20):e2300641.
PMID: 38629187
Human embryonic stem cells (hESCs) resemble the pluripotent epiblast cells found in the early postimplantation human embryo and represent the "primed" state of pluripotency. One factor that helps primed pluripotent...
3.
HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver
Deans J, Deol P, Titova N, Radi S, Vuong L, Evans J, et al.
Front Endocrinol (Lausanne)
. 2023 Dec;
14:1266527.
PMID: 38111711
Hepatocyte Nuclear Factor 4α (HNF4α), a master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2) which drive the expression of different isoforms. P1-HNF4α is the major...
4.
Brindani N, Vuong L, Acquistapace I, La Serra M, Ortega J, Veronesi M, et al.
J Med Chem
. 2023 Apr;
66(8):5981-6001.
PMID: 37026468
CDC42 GTPases (RHOJ, CDC42, and RHOQ) are overexpressed in multiple tumor types and activate pathways critical for tumor growth, angiogenesis, and metastasis. Recently, we reported the discovery of a novel...
5.
Jahid S, Ortega J, Vuong L, Acquistapace I, Hachey S, Flesher J, et al.
Cell Rep
. 2022 Apr;
39(4):110760.
PMID: 35476990
No abstract available.
6.
Jahid S, Ortega J, Vuong L, Acquistapace I, Hachey S, Flesher J, et al.
Cell Rep
. 2022 Apr;
39(1):110641.
PMID: 35385746
CDC42 family GTPases (RHOJ, RHOQ, CDC42) are upregulated but rarely mutated in cancer and control both the ability of tumor cells to invade surrounding tissues and the ability of endothelial...
7.
Vuong L, Pan S, Donovan P
Proteomics
. 2019 Jun;
19(15):e1900169.
PMID: 31219246
Long Interspersed Element-1 (LINE-1 or L1) are transposable elements similar to retroviruses that have existed in the genome of primates for millions of years. They encode two Open Reading Frame...
8.
TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency
Sierra R, Hoverter N, Ramirez R, Vuong L, Mortazavi A, Merrill B, et al.
Development
. 2018 Jan;
145(4).
PMID: 29361574
Human embryonic stem cells (hESCs) are exquisitely sensitive to WNT ligands, which rapidly cause differentiation. Therefore, hESC self-renewal requires robust mechanisms to keep the cells in a WNT inactive but...
9.
Chellappa K, Deol P, Evans J, Vuong L, Chen G, Briancon N, et al.
Elife
. 2016 May;
5.
PMID: 27166517
HNF4α has been implicated in colitis and colon cancer in humans but the role of the different HNF4α isoforms expressed from the two different promoters (P1 and P2) active in...
10.
Vuong L, Chellappa K, Dhahbi J, Deans J, Fang B, Bolotin E, et al.
Mol Cell Biol
. 2015 Aug;
35(20):3471-90.
PMID: 26240283
The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) is tumor suppressive in the liver but amplified in colon cancer, suggesting that it also might be oncogenic. To investigate whether this...