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Lina Josefsson

Explore the profile of Lina Josefsson including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 585
Followers 0
Related Specialties
Microbiology
Science
Infectious Diseases
Top 10 Co-Authors
Sarah Palmer
Wei Shao
Nuno R Faria
Peter Bacchetti
Maudi Killian
Lisa Loeb
Jeff Custer
Lorrie Epling
Frank Maldarelli
John M Coffin
Published In
Proc Natl Acad Sci U S A
PLoS Pathog
Antiviral Res
Curr Opin Infect Dis
J Infect Dis
Affiliations
Soon will be listed here.
Recent Articles
1.
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time
Josefsson L, von Stockenstrom S, Faria N, Sinclair E, Bacchetti P, Killian M, et al.
Proc Natl Acad Sci U S A . 2013 Nov; 110(51):E4987-96. PMID: 24277811
The source and dynamics of persistent HIV-1 during long-term combinational antiretroviral therapy (cART) are critical to understanding the barriers to curing HIV-1 infection. To address this issue, we isolated and...
2.
Single cell analysis of lymph node tissue from HIV-1 infected patients reveals that the majority of CD4+ T-cells contain one HIV-1 DNA molecule
Josefsson L, Palmer S, Faria N, Lemey P, Casazza J, Ambrozak D, et al.
PLoS Pathog . 2013 Jul; 9(6):e1003432. PMID: 23818847
Genetic recombination contributes to the diversity of human immunodeficiency virus (HIV-1). Productive HIV-1 recombination is, however, dependent on both the number of HIV-1 genomes per infected cell and the genetic...
3.
Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA
Josefsson L, Eriksson S, Sinclair E, Ho T, Killian M, Epling L, et al.
J Infect Dis . 2012 Apr; 206(1):28-34. PMID: 22536001
Background: We address the key emerging question of whether Lin(-)/CD34(+) hematopoietic precursor cells (HPCs) represent an important latent reservoir of human immunodeficiency virus type 1 (HIV-1) during long-term suppressive therapy....
4.
Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule
Josefsson L, King M, Makitalo B, Brannstrom J, Shao W, Maldarelli F, et al.
Proc Natl Acad Sci U S A . 2011 Jun; 108(27):11199-204. PMID: 21690402
Neither the number of HIV-1 proviruses within individual infected cells in HIV-1-infected patients nor their genetic relatedness within individual infected cells and between cells and plasma virus are well defined....
5.
Uropathogenic Escherichia coli P and Type 1 fimbriae act in synergy in a living host to facilitate renal colonization leading to nephron obstruction
Melican K, Sandoval R, Kader A, Josefsson L, Tanner G, Molitoris B, et al.
PLoS Pathog . 2011 Mar; 7(2):e1001298. PMID: 21383970
The progression of a natural bacterial infection is a dynamic process influenced by the physiological characteristics of the target organ. Recent developments in live animal imaging allow for the study...
6.
Can HIV infection be eradicated through use of potent antiviral agents?
Josefsson L, Dahl V, Palmer S
Curr Opin Infect Dis . 2010 Sep; 23(6):628-32. PMID: 20847693
Purpose Of Review: This review focuses on recent advances in HIV research and therapy that seek to eradicate persistent HIV in patients on suppressive therapy. Recent Findings: The source of...
7.
HIV reservoirs, latency, and reactivation: prospects for eradication
Dahl V, Josefsson L, Palmer S
Antiviral Res . 2009 Oct; 85(1):286-94. PMID: 19808057
Current antiretroviral therapy effectively suppresses but does not eradicate HIV-1 infection. During therapy patients maintain a persistent low-level viremia requiring lifelong adherence to antiretroviral therapies. This viremia may arise from...