Lina Freage
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Explore the profile of Lina Freage including associated specialties, affiliations and a list of published articles.
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10
Citations
133
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Recent Articles
1.
Boykoff N, Freage L, Lenn J, Mallikaratchy P
ACS Omega
. 2021 Dec;
6(48):32563-32570.
PMID: 34901605
The current detection methods of malignant cells are mainly based on the high expression levels of certain surface proteins on these cells. However, many of the same surface marker proteins...
2.
Freage L, Boykoff N, Mallikaratchy P
ACS Omega
. 2021 May;
6(19):12382-12391.
PMID: 34056390
DNA nanotechnology is undergoing rapid progress in the assembly of functional devices with biological relevance. In particular, currently, the research attention is more focused on the application of nanodevices at...
3.
Freage L, Jamal D, Williams N, Mallikaratchy P
Mol Ther Nucleic Acids
. 2020 Sep;
22:167-178.
PMID: 32920262
Recently, immunotherapeutic modalities with engineered cells and monoclonal antibodies have been effective in treating several malignancies. Nucleic acid aptamers can serve as alternative molecules to design immunotherapeutic agents with high...
4.
Freage L, Trifonov A, Tel-Vered R, Golub E, Wang F, McCaskill J, et al.
Chem Sci
. 2018 Mar;
6(6):3544-3549.
PMID: 29511515
The design of artificial cells, which mimic the functions of native cells, is an ongoing scientific goal. The development of stimuli-responsive chemical systems that stimulate cascaded catalytic transformations, trigger chemical...
5.
Kahn J, Freage L, Enkin N, Aleman Garcia M, Willner I
Adv Mater
. 2016 Dec;
29(6).
PMID: 27922207
The synthesis of nucleic acid-functionalized metal-organic frameworks (MOFs) is described. The metal-organic frameworks are loaded with a dye being locked in the structures by means of stimuli-responsive nucleic acid caps....
6.
Heleg-Shabtai V, Aizen R, Sharon E, Sohn Y, Trifonov A, Enkin N, et al.
ACS Appl Mater Interfaces
. 2016 May;
8(23):14414-22.
PMID: 27186957
Mesoporous SiO2 nanoparticles, MP-SiO2 NPs, are functionalized with the boronic acid ligand units. The pores of the MP-SiO2 NPs are loaded with the anticancer drug mitoxantrone, and the pores are...
7.
Freage L, Wang F, Orbach R, Willner I
Anal Chem
. 2014 Nov;
86(22):11326-33.
PMID: 25369533
The progressive development of amplified DNA sensors using nucleic acid-based machineries, involving the isothermal autonomous synthesis of the Mg(2+)-dependent DNAzyme, is used for the amplified, multiplexed analysis of genes (Smallpox,...
8.
Guo W, Qi X, Orbach R, Lu C, Freage L, Mironi-Harpaz I, et al.
Chem Commun (Camb)
. 2014 Mar;
50(31):4065-8.
PMID: 24616906
DNA hydrogels, consisting of Y-shaped nucleic acid subunits or of nucleic acid-functionalized acrylamide chains, undergo switchable gel-to-solution transitions. The Ag(+)-stimulated formation of cytosine-Ag(+)-cytosine complexes results in the crosslinking of the...
9.
Wang F, Lu C, Liu X, Freage L, Willner I
Anal Chem
. 2014 Jan;
86(3):1614-21.
PMID: 24377284
The amplified, highly sensitive detection of DNA using the dendritic rolling circle amplification (RCA) is introduced. The analytical platform includes a circular DNA and a structurally tailored hairpin structure. The...
10.
Wang F, Freage L, Orbach R, Willner I
Anal Chem
. 2013 Jul;
85(17):8196-203.
PMID: 23883398
The progressive development of amplified DNA sensors and aptasensors using replication/nicking enzymes/DNAzyme machineries is described. The sensing platforms are based on the tailoring of a DNA template on which the...