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Limor Man

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Articles 17
Citations 134
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Recent Articles
1.
Lustgarten Guahmich N, Man L, Wang J, Arazi L, Kallinos E, Topper-Kroog A, et al.
Commun Biol . 2023 Jan; 6(1):7. PMID: 36599970
Theca cells serve multiple essential functions during the growth and maturation of ovarian follicles, providing structural, metabolic, and steroidogenic support. While the function of theca during folliculogenesis is well established,...
2.
Man L, Lustgarten Guahmich N, Kallinos E, Arazi L, Rosenwaks Z, James D
J Vis Exp . 2022 Dec; (189). PMID: 36533813
The activation, growth, development, and maturation of oocytes is a complex process that is coordinated not just between multiple cell types of the ovary but also across multiple points of...
3.
Man L, Lustgarten Guahmich N, Vyas N, Tsai S, Arazi L, Lilienthal D, et al.
Int J Mol Sci . 2022 Dec; 23(23). PMID: 36499748
The ovarian reserve is finite and begins declining from its peak at mid-gestation until only residual follicles remain as women approach menopause. Reduced ovarian reserve, or its extreme form, premature...
4.
Man L, Lustgarten Guahmich N, Kallinos E, Park L, Bodine R, Zaninovic N, et al.
Reproduction . 2022 Oct; 165(1):31-47. PMID: 36194429
In Brief: Xenografts of human ovarian cortical tissue provide a tractable model of heterotopic autotransplantation that is used for fertility preservation in patients undergoing ablative chemo/radiotherapy. This study describes the...
5.
Man L, Lustgarten Guahmich N, Kallinos E, Park L, Caiazza B, Khan M, et al.
F S Sci . 2022 May; 2(3):237-247. PMID: 35560275
Objective: To measure the influence of exogenous insulin-like growth factor 1 (IGF1) on follicle growth and maturation in human ovarian cortical xenografts. Design: Xenotransplantation model. Setting: University-based research laboratory. Patients/animals:...
6.
Man L, Lustgarten Guahmich N, Kallinos E, Caiazza B, Khan M, Liu Z, et al.
Sci Adv . 2022 Mar; 8(10):eabi7315. PMID: 35263130
Anti-Müllerian hormone (AMH) is produced by growing ovarian follicles and provides a diagnostic measure of reproductive reserve in women; however, the impact of AMH on folliculogenesis is poorly understood. We...
7.
Man L, Lustgarten-Guahmich N, Kallinos E, Redhead-Laconte Z, Liu S, Schattman B, et al.
Cell Rep . 2020 Aug; 32(6):108027. PMID: 32783948
The activation, growth, and maturation of oocytes to an ovulatory phase, termed folliculogenesis, is governed by the orchestrated activity of multiple specialized cell types within the ovary; yet, the mechanisms...
8.
Man L, Lekovich J, Canon C, Rosenwaks Z, James D
Fertil Steril . 2020 Jun; 113(6):1205-1214. PMID: 32482254
Objective: To study whether patients exhibiting poor ovarian response have abnormal levels of serum insulin-like growth factor (IGF)-1 on cycle day 2 when compared with age-matched normal and high responders....
9.
Man L, Park L, Bodine R, Ginsberg M, Zaninovic N, Schattman G, et al.
J Vis Exp . 2018 Jun; (135). PMID: 29863664
Infertility is a frequent side effect of chemotherapy and/or radiotherapy and for some patients, cryopreservation of oocytes or embryos is not an option. As an alternative, an increasing number of...
10.
Lekovich J, Man L, Xu K, Canon C, Lilienthal D, Stewart J, et al.
Genet Med . 2017 Dec; 20(9):957-964. PMID: 29267266
Purpose: Fragile X premutation (PM) carriers may experience difficulties conceiving a child probably due to fragile X-associated diminished ovarian reserve (FXDOR). We investigated which subgroups of carriers with a PM...