Ligia Westrich
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Explore the profile of Ligia Westrich including associated specialties, affiliations and a list of published articles.
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9
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99
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Recent Articles
1.
Kim D, Ryba N, Kalabalik J, Westrich L
Drugs R D
. 2018 Sep;
18(3):167-189.
PMID: 30171515
Currently, all second-generation antipsychotics are approved for schizophrenia. Many are also approved for bipolar disorder, with some also approved as adjunctive treatment for depression and autism-related irritability. Second-generation antipsychotics are...
2.
Kugathasan P, Waller J, Westrich L, Abdourahman A, Tamm J, Pehrson A, et al.
J Psychopharmacol
. 2016 Sep;
31(3):365-376.
PMID: 27678087
Neuroplasticity is fundamental for brain functions, abnormal changes of which are associated with mood disorders and cognitive impairment. Neuroplasticity can be affected by neuroactive medications and by aging. Vortioxetine, a...
3.
Leiser S, Iglesias-Bregna D, Westrich L, Pehrson A, Sanchez C
J Psychopharmacol
. 2015 Jul;
29(10):1092-105.
PMID: 26174134
Antidepressants often disrupt sleep. Vortioxetine, a multimodal antidepressant acting through serotonin (5-HT) transporter (SERT) inhibition, 5-HT3, 5-HT7 and 5-HT1D receptor antagonism, 5-HT1B receptor partial agonism, and 5-HT1A receptor agonism, had...
4.
Westrich L, Haddjeri N, Dkhissi-Benyahya O, Sanchez C
Neuropharmacology
. 2014 Dec;
89:382-90.
PMID: 25446573
Since poor circadian synchrony and cognitive dysfunction have been linked to affective disorders, antidepressants that target key 5-HT (serotonin) receptor subtypes involved in circadian rhythm and cognitive regulation may have...
5.
Westrich L, Sprouse J, Sanchez C
Physiol Behav
. 2013 Jan;
110-111:42-50.
PMID: 23276605
Disruption of circadian rhythms may lead to mood disorders. The present study investigated the potential therapeutic utility of combining a 5-HT7 antagonist with a selective serotonin (5-HT) reuptake inhibitor (SSRI),...
6.
Westrich L, Sprouse J
Curr Opin Investig Drugs
. 2010 Jun;
11(7):779-87.
PMID: 20571973
When circadian rhythms - the daily oscillations of various physiological and behavioral events that are controlled by a central timekeeping mechanism - become desynchronized with the prevailing light:dark cycle, a...
7.
Westrich L, Gil-Mast S, Kortagere S, Kuzhikandathil E
Biochem Pharmacol
. 2009 Nov;
79(6):897-907.
PMID: 19879251
The D3 but not D2 dopamine receptors exhibit a tolerance property in which agonist-induced D3 receptor response progressively decreases upon repeated agonist stimulation. We have previously shown that the D3...
8.
Westrich L, Kuzhikandathil E
Biochim Biophys Acta
. 2007 Jul;
1773(12):1747-58.
PMID: 17662480
The D2 and D3 dopamine receptor subtypes are structurally homologous and couple to the same signal transduction pathways. Nevertheless, their evolutionary conservation suggests that the two subtypes might exhibit unique...
9.
Kuzhikandathil E, Westrich L, Bakhos S, Pasuit J
Mol Cell Neurosci
. 2004 May;
26(1):144-55.
PMID: 15121186
Among dopamine receptors, the function and properties of the D3 receptor subtype are poorly understood. Here we report the identification and characterization of two unique properties of the human D3...