Leticia K Lerner
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Explore the profile of Leticia K Lerner including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
137
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Recent Articles
1.
Lerner L, Bonte D, Le Guillou M, Mohammad M, Kasraian Z, Sarasin A, et al.
Front Immunol
. 2024 Jun;
15:1419493.
PMID: 38840919
[This corrects the article DOI: 10.3389/fimmu.2022.871766.].
2.
Jondreville L, Dehgane L, Doualle C, Smagghe L, Grange B, Davi F, et al.
Leukemia
. 2023 Sep;
37(11):2221-2230.
PMID: 37752286
Chronic lymphocytic leukemia (CLL) is a heterogeneous disease, the prognosis of which varies according to the cytogenetic group. We characterized a rare chromosomal abnormality (del(8p), deletion of the short arm...
3.
Lerner L, Bonte D, Le Guillou M, Mohammad M, Kasraian Z, Sarasin A, et al.
Front Immunol
. 2022 Apr;
13:871766.
PMID: 35432321
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a B cell specific process required for the generation of specific and high affinity antibodies during the maturation of the immune response...
4.
Lerner L, Holzer S, Kilkenny M, Svikovic S, Murat P, Schiavone D, et al.
EMBO J
. 2020 Jul;
39(18):e104185.
PMID: 32705708
Regions of the genome with the potential to form secondary DNA structures pose a frequent and significant impediment to DNA replication and must be actively managed in order to preserve...
5.
Delavallee L, Mathiah N, Cabon L, Mazeraud A, Brunelle-Navas M, Lerner L, et al.
Mol Metab
. 2020 Jun;
40:101027.
PMID: 32480041
Objectives: Apoptosis-Inducing Factor (AIF) is a protein involved in mitochondrial electron transport chain assembly/stability and programmed cell death. The relevant role of this protein is underlined because mutations altering mitochondrial...
6.
Lerner L, Nguyen T, Castro L, Vilar J, Munford V, Le Guillou M, et al.
Sci Rep
. 2020 Jan;
10(1):1311.
PMID: 31992747
Somatic hypermutation of immunoglobulin genes is a highly mutagenic process that is B cell-specific and occurs during antigen-driven responses leading to antigen specificity and antibody affinity maturation. Mutations at the...
7.
Lerner L, Moreno N, Rocha C, Munford V, Santos V, Soltys D, et al.
Mutagenesis
. 2019 Jul;
34(4):341-354.
PMID: 31348825
Nucleotide excision repair (NER) is a conserved, flexible mechanism responsible for the removal of bulky, helix-distorting DNA lesions, like ultraviolet damage or cisplatin adducts, but its role in the repair...
8.
Quinet A, Lerner L, Martins D, Menck C
Mutat Res Genet Toxicol Environ Mutagen
. 2018 Nov;
836(Pt B):127-142.
PMID: 30442338
During DNA replication, forks may encounter unrepaired lesions that hamper DNA synthesis. Cells have universal strategies to promote damage bypass allowing cells to survive. DNA damage tolerance can be performed...
9.
Lerner L, Francisco G, Soltys D, Rocha C, Quinet A, Vessoni A, et al.
Nucleic Acids Res
. 2017 Feb;
45(3):1270-1280.
PMID: 28180309
Genome lesions trigger biological responses that help cells manage damaged DNA, improving cell survival. Pol eta is a translesion synthesis (TLS) polymerase that bypasses lesions that block replicative polymerases, avoiding...
10.
Soltys D, Rocha C, Lerner L, de Souza T, Munford V, Cabral F, et al.
Hum Mutat
. 2012 Dec;
34(3):481-9.
PMID: 23255472
Nucleotide excision repair (NER) is the most flexible of all known DNA-repair mechanisms, and XPG is a 3'-endonuclease that participates in NER. Mutations in this gene (ERCC5) may result in...