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Leslie Spangler

Explore the profile of Leslie Spangler including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 755
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Recent Articles
1.
Curtis J, Arora T, Liu Y, Lin T, Spangler L, Brunetti V, et al.
J Bone Miner Res . 2024 May; 39(7):826-834. PMID: 38753892
Although clinical trials have shown that denosumab significantly increases bone mineral density at key skeletal sites more than oral bisphosphonates, evidence is lacking from head-to-head randomized trials evaluating fracture outcomes....
2.
Spangler L, Nielson C, Brookhart M, Hernandez R, Stad R, Lin T
JBMR Plus . 2023 Oct; 7(10):e10793. PMID: 37808402
Osteoporosis and cardiovascular disease are common in older adults. Treatment of osteoporosis reduces the burden of debilitating fractures; however, it is important to understand the benefit versus risk of treatment....
3.
Kim M, Lin T, Arora T, Zhao H, Balasubramanian A, Stad R, et al.
J Bone Miner Res . 2023 Apr; 38(6):829-840. PMID: 37088886
It is often difficult to obtain valid estimates of comparative treatment effectiveness and safety owing to differences across patient populations taking different medications in the real world. One approach for...
4.
Stevens L, Spangler L, Yochum L, Ding Y, Wang F
Clin Epidemiol . 2021 Nov; 13:1019-1026. PMID: 34737646
Purpose: Medication-related osteonecrosis of jaw (MRONJ) is associated with certain drug therapies. Pharmacoepidemiologic studies often rely on electronic healthcare data to assess adverse events following drug exposure. Few studies have...
5.
McGrath L, Spangler L, Curtis J, Ehrenstein V, Sorensen H, Saul B, et al.
Pharmacoepidemiol Drug Saf . 2020 Jun; 29(8):854-863. PMID: 32537883
Purpose: In contrast to randomized clinical trials, comparative safety and effectiveness assessments of osteoporosis medications in clinical practice may be subject to confounding by indication. We used negative control outcomes...
6.
Lau A, Wong-Pack M, Rodjanapiches R, Ioannidis G, Wade S, Spangler L, et al.
J Rheumatol . 2017 Nov; 45(2):170-176. PMID: 29142041
Objective: Previous studies combining biologic disease-modifying antirheumatic drugs (bDMARD) to treat rheumatoid arthritis (RA) have shown an increased risk of infection. However, the risk of infection with concurrent use of...
7.
Scholes D, LaCroix A, Hubbard R, Ichikawa L, Spangler L, Operskalski B, et al.
Menopause . 2016 Jan; 23(2):166-74. PMID: 26757274
Objective: The effect of oral contraceptive (OC) use on risk of fracture remains unclear, and use during later reproductive life may be increasing. To determine the association between OC use...
8.
Cheng L, Durden E, Limone B, Radbill L, Juneau P, Spangler L, et al.
J Manag Care Spec Pharm . 2015 Aug; 21(9):824-33, 833a. PMID: 26308229
Background: Prior research has shown that rates of persistence and compliance with osteoporosis therapies are associated with significantly fewer vertebral, nonvertebral, and hip fractures. A number of studies have examined...
9.
Ferguson S, Tepie M, Taylor A, Roddam A, Critchlow C, Iqbal M, et al.
J Eval Clin Pract . 2015 Aug; 22(1):31-39. PMID: 26279458
Rationale, Aims And Objectives: Clinical trial data suggest that patients who have received bisphosphonates continue to benefit from them after discontinuation. However, data from real-world clinical practice are inconclusive. We...
10.
Singer A, Exuzides A, Spangler L, OMalley C, Colby C, Johnston K, et al.
Mayo Clin Proc . 2014 Dec; 90(1):53-62. PMID: 25481833
Objectives: To provide a national estimate of the incidence of hospitalizations due to osteoporotic fractures (OFs) in women; compare this with the incidence of myocardial infarction (MI), stroke, and breast...