Leonore A Herzenberg
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Explore the profile of Leonore A Herzenberg including associated specialties, affiliations and a list of published articles.
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82
Citations
4013
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Recent Articles
1.
Ghosh D, Pham T, Nanaware P, Sengupta D, Adler L, Li C, et al.
Cell Rep
. 2022 Jan;
38(4):110200.
PMID: 35081339
The non-classical Major Histocompatibility Complex class II (MHCII) protein, H2-M, edits peptides bound to conventional MHCII in favor of stable peptide/MHCII (p/MHCII) complexes. Here, we show that H2-M deficiency affects...
2.
Eddins D, Kosters A, Waters J, Sosa J, Phillips M, Yadava K, et al.
J Immunol
. 2021 Nov;
207(12):3028-3037.
PMID: 34810224
Tissue-resident macrophages (TRMΦ) are important immune sentinels responsible for maintaining tissue and immune homeostasis within their specific niche. Recently, the origins of TRMΦ have undergone intense scrutiny, in which now...
3.
Gifani M, Eddins D, Kosuge H, Zhang Y, Paluri S, Larson T, et al.
Adv Funct Mater
. 2021 Nov;
31(37).
PMID: 34733130
Disruption of vulnerable atherosclerotic plaques often leads to myocardial infarction and stroke, the leading causes of morbidity and mortality in the United States. A diagnostic method that detects high-risk atherosclerotic...
4.
Li W, Yang Y, Guo T, Sahbaie P, Shi X, Guang Q, et al.
Brain Behav Immun
. 2021 Feb;
94:148-158.
PMID: 33636311
Background: Up-regulated interleukin 6 (IL-6) signaling, immune system activation, and pronociceptive autoantibodies are characteristic of complex regional pain syndrome (CRPS). IL-6 is known to promote B cell differentiation, thus we...
5.
Yang Y, Li X, Ma Z, Wang C, Yang Q, Byrne-Steele M, et al.
Nat Commun
. 2021 Jan;
12(1):525.
PMID: 33483505
CTLA-4 is an important regulator of T-cell function. Here, we report that expression of this immune-regulator in mouse B-1a cells has a critical function in maintaining self-tolerance by regulating these...
6.
Li W, Yang Y, Shi X, Guo T, Guang Q, Kingery W, et al.
Brain Behav Immun
. 2020 May;
88:725-734.
PMID: 32413559
Emerging evidence suggests that Complex Regional Pain Syndrome (CRPS) is in part a post-traumatic autoimmune disease mediated by an adaptive immune response after limb injuries. We previously observed in a...
7.
Ghosn E, Yoshimoto M, Nakauchi H, Weissman I, Herzenberg L
Development
. 2019 Aug;
146(15).
PMID: 31371526
The current paradigm that a single long-term hematopoietic stem cell can regenerate all components of the mammalian immune system has been challenged by recent findings in mice. These findings show...
8.
Meehan S, Kolyagin G, Parks D, Youngyunpipatkul J, Herzenberg L, Walther G, et al.
Commun Biol
. 2019 Jun;
2:229.
PMID: 31240267
When examining datasets of any dimensionality, researchers frequently aim to identify individual subsets (clusters) of objects within the dataset. The ubiquity of multidimensional data has motivated the replacement of user-guided...
9.
Ghosn E, Dorshkind K, Herzenberg L, Holodick N, Kantor A, Montecino-Rodriguez E, et al.
Science
. 2019 Apr;
364(6437):248.
PMID: 31000655
No abstract available.
10.
Orlova D, Meehan S, Parks D, Moore W, Meehan C, Zhao Q, et al.
Sci Rep
. 2018 Feb;
8(1):3291.
PMID: 29459702
Part of the flow/mass cytometry data analysis process is aligning (matching) cell subsets between relevant samples. Current methods address this cluster-matching problem in ways that are either computationally expensive, affected...