Leoni A Kunz-Schughart
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Explore the profile of Leoni A Kunz-Schughart including associated specialties, affiliations and a list of published articles.
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91
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5205
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Recent Articles
1.
Blondeel E, Peirsman A, Vermeulen S, Piccinini F, De Vuyst F, Estevao D, et al.
Sci Data
. 2025 Feb;
12(1):283.
PMID: 39962061
The application of three-dimensional (3D) cell cultures such as spheroids and organoids is growing in popularity both in academia and industry. However, morphology of the 3D architecture remains remarkably understudied....
2.
De Mendoza A, De Mendoza A, Michliikova S, Michlikova S, Castro P, Castro P, et al.
Phys Med Biol
. 2025 Jan;
70(2.
PMID: 39761642
. Mathematical modeling can offer valuable insights into the behavior of biological systems upon treatment. Different mathematical models (empirical, semi-empirical, and mechanistic) have been designed to predict the efficacy of...
3.
Klemt I, Reshetnikov V, Dutta S, Bila G, Bilyy R, Cuartero I, et al.
RSC Med Chem
. 2024 Apr;
15(4):1189-1197.
PMID: 38665843
Many known chemotherapeutic anticancer agents exhibit neutropenia as a dose-limiting side effect. In this paper we suggest a prodrug concept solving this problem for camptothecin (HO-cpt). The prodrug is programmed...
4.
Franke F, Michlikova S, Aland S, Kunz-Schughart L, Voss-Bohme A, Lange S
Cancers (Basel)
. 2023 Dec;
15(23).
PMID: 38067348
Understanding the complex dynamics of tumor growth to develop more efficient therapeutic strategies is one of the most challenging problems in biomedicine. Three-dimensional (3D) tumor spheroids, reflecting avascular microregions within...
5.
Blankenstein L, Cordes N, Kunz-Schughart L, Vehlow A
Cells
. 2022 Jul;
11(14).
PMID: 35883575
Glioblastoma is a devastating malignant disease with poor patient overall survival. Strong invasiveness and resistance to radiochemotherapy have challenged the identification of molecular targets that can finally improve treatment outcomes....
6.
Koseer A, Loureiro L, Jureczek J, Mitwasi N, Soto K, Aepler J, et al.
Cancers (Basel)
. 2022 Apr;
14(7).
PMID: 35406454
Most patients with head and neck squamous cell carcinomas (HNSCC) are diagnosed at a locally advanced stage and show heterogeneous treatment responses. Low (solute carrier family 3 member 2) mRNA...
7.
Xu H, Reshetnikov V, Wondrak M, Eckhardt L, Kunz-Schughart L, Janko C, et al.
Cancers (Basel)
. 2022 Jan;
14(1).
PMID: 35008371
Radiotherapy (RT) efficacy can be improved by using radiosensitizers, i.e., drugs enhancing the effect of ionizing radiation (IR). One of the side effects of RT includes damage of normal tissue...
8.
Peirsman A, Blondeel E, Ahmed T, Anckaert J, Audenaert D, Boterberg T, et al.
Nat Methods
. 2021 Nov;
18(11):1294-1303.
PMID: 34725485
Spheroids are three-dimensional cellular models with widespread basic and translational application across academia and industry. However, methodological transparency and guidelines for spheroid research have not yet been established. The MISpheroID...
9.
Suckert T, Nexhipi S, Dietrich A, Koch R, Kunz-Schughart L, Bahn E, et al.
Cancers (Basel)
. 2021 Aug;
13(16).
PMID: 34439370
The number of proton therapy centers worldwide are increasing steadily, with more than two million cancer patients treated so far. Despite this development, pending questions on proton radiobiology still call...
10.
Mukha A, Kahya U, Linge A, Chen O, Lock S, Lukiyanchuk V, et al.
Theranostics
. 2021 Aug;
11(16):7844-7868.
PMID: 34335968
Radiotherapy is one of the curative treatment options for localized prostate cancer (PCa). The curative potential of radiotherapy is mediated by irradiation-induced oxidative stress and DNA damage in tumor cells....