Leonardo H Tonelli
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Explore the profile of Leonardo H Tonelli including associated specialties, affiliations and a list of published articles.
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43
Citations
1063
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Recent Articles
1.
Georgiou P, Zanos P, Mou T, An X, Gerhard D, Dryanovski D, et al.
Nat Neurosci
. 2022 Aug;
25(9):1191-1200.
PMID: 36042309
We show that the sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant ketamine and its bioactive metabolite (2R,6R)-hydroxynorketamine. Mice showed aversion to the...
2.
Mou T, Lane M, Ireland D, Verthelyi D, Tonelli L, Clark S
Neurobiol Dis
. 2022 Aug;
173:105840.
PMID: 35995342
An early inflammatory insult is the most recognized risk factor associated with neurodevelopmental psychiatric disorders, even more so than genetic variants. Notably, complement component 4 (C4), a molecule involved in...
3.
Ireland D, Manangeeswaran M, Lewkowicz A, Engel K, Clark S, Laniyan A, et al.
PLoS Pathog
. 2020 Dec;
16(12):e1008689.
PMID: 33301527
The neurodevelopmental defects associated with ZIKV infections early in pregnancy are well documented, however the potential defects and long-term consequences associated with milder infections in late pregnancy and perinatal period...
4.
Albrecht M, Vaughn C, Erickson M, Clark S, Tonelli L
PLoS One
. 2018 Nov;
13(11):e0206985.
PMID: 30418990
Research has shown that inflammatory processes affect brain function and behavior through several neuroimmune pathways. However, high order brain functions affected by inflammation largely remain to be defined. Resting state...
5.
Clark S, Notarangelo F, Li X, Chen S, Schwarcz R, Tonelli L
Prog Neuropsychopharmacol Biol Psychiatry
. 2018 Sep;
89:286-294.
PMID: 30267854
Maternal immune activation (MIA) with the viral mimic poly I:C provides an established rodent model for studying schizophrenia (SZ) and other human neurodevelopmental disorders. Postnatal infections are additional risk factors...
6.
Kelly D, Li X, Kilday C, Feldman S, Clark S, Liu F, et al.
Psychiatry Res
. 2018 Sep;
269:517-523.
PMID: 30195746
Immunological abnormalities are increasingly reported in people with schizophrenia, but no clear functional biomarkers associated with genetic correlates of the disease have been found. Regulatory T cells (Tregs) are key...
7.
Clark S, Song C, Li X, Keegan A, Tonelli L
Cytokine
. 2018 Jul;
113:256-264.
PMID: 30033139
Psychological stress is known to have profound effects on immune function and to promote inflammatory conditions. Elevated circulating levels of cytokines associated with stress are known to increase the risk...
8.
Clark S, Vaughn C, Soroka J, Li X, Tonelli L
Eur J Neurosci
. 2018 Feb;
47(8):968-978.
PMID: 29430738
Accumulating evidence has shown that lymphocytes modulate behaviour and cognition by direct interactions with the central nervous system. Studies have shown that reconstitution by adoptive transfer of lymphocytes from wild...
9.
Song C, Clark S, Vaughn C, Nicholson J, Murphy K, Mou T, et al.
Neuroscience
. 2017 Nov;
369:1-14.
PMID: 29126954
Kynurenic acid, a metabolite of the kynurenine pathway of tryptophan degradation, acts as an endogenous antagonist of alpha7 nicotinic and NMDA receptors and is implicated in a number of neurophysiological...
10.
Clark S, Soroka J, Song C, Li X, Tonelli L
Stress
. 2016 Jun;
19(3):303-11.
PMID: 27295202
Accumulating evidence supports a role of T cells in behavioral stress responsiveness. Our laboratory previously reported that lymphocyte deficient Rag2(-/-) mice on a BALB/c background display resilience to maladaptive stress...