Leonard R Pelgrom
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Explore the profile of Leonard R Pelgrom including associated specialties, affiliations and a list of published articles.
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15
Citations
434
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Recent Articles
1.
Pelgrom L, Davis G, OShaughnessy S, Wezenberg E, van Kasteren S, Finlay D, et al.
Cell Rep
. 2023 Jul;
42(8):112828.
PMID: 37478011
System-level analysis of single-cell data is rapidly transforming the field of immunometabolism. Given the competitive demand for nutrients in immune microenvironments, there is a need to understand how and when...
2.
van der Zande H, Brombacher E, Lambooij J, Pelgrom L, Zawistowska-Deniziak A, Patente T, et al.
JCI Insight
. 2023 May;
8(11).
PMID: 37140993
Obesity-associated metabolic inflammation drives the development of insulin resistance and type 2 diabetes, notably through modulating innate and adaptive immune cells in metabolic organs. The nutrient sensor liver kinase B1...
3.
Pelgrom L, Patente T, Otto F, Nouwen L, Ozir-Fazalalikhan A, van der Ham A, et al.
Cell Rep
. 2022 Jul;
40(1):111032.
PMID: 35793635
How mechanistic target of rapamycin complex 1 (mTORC1), a key regulator of cellular metabolism, affects dendritic cell (DC) metabolism and T cell-priming capacity has primarily been investigated in vitro, but...
4.
Embgenbroich M, van der Zande H, Hussaarts L, Schulte-Schrepping J, Pelgrom L, Garcia-Tardon N, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(31).
PMID: 34326259
Proinflammatory activation of macrophages in metabolic tissues is critically important in the induction of obesity-induced metaflammation. Here, we demonstrate that the soluble mannose receptor (sMR) plays a direct functional role...
5.
van der Zande H, Gonzalez M, de Ruiter K, Wilbers R, Garcia-Tardon N, van Huizen M, et al.
FASEB J
. 2021 Jan;
35(2):e21331.
PMID: 33476078
Type 2 immunity plays an essential role in the maintenance of metabolic homeostasis and its disruption during obesity promotes meta-inflammation and insulin resistance. Infection with the helminth parasite Schistosoma mansoni...
6.
Winkel B, Pelgrom L, van Schuijlenburg R, Baalbergen E, Ganesh M, Gerritsma H, et al.
PLoS Pathog
. 2020 Sep;
16(9):e1008799.
PMID: 32898164
Professional antigen-presenting cells (APCs), like macrophages (Mϕs) and dendritic cells (DCs), are central players in the induction of natural and vaccine-induced immunity to malaria, yet very little is known about...
7.
Thwe P, Pelgrom L, Cooper R, Beauchamp S, Reisz J, DAlessandro A, et al.
Cell Metab
. 2019 Jul;
30(1):225.
PMID: 31269426
No abstract available.
8.
Pelgrom L, Patente T, Sergushichev A, Esaulova E, Otto F, Ozir-Fazalalikhan A, et al.
Cell Res
. 2019 Apr;
29(5):406-419.
PMID: 30940876
Liver Kinase B1 (LKB1) plays a key role in cellular metabolism by controlling AMPK activation. However, its function in dendritic cell (DC) biology has not been addressed. Here, we find...
9.
Patente T, Pelgrom L, Everts B
Curr Opin Immunol
. 2019 Mar;
58:16-23.
PMID: 30875606
Dendritic cells (DCs) are professional antigen-presenting cells that play a crucial role in the priming and differentiation of CD4 T cells into several distinct subsets including effector T helper (Th)...
10.
Kaisar M, Ritter M, Del Fresno C, Jonasdottir H, van der Ham A, Pelgrom L, et al.
PLoS Biol
. 2018 Apr;
16(4):e2005504.
PMID: 29668708
The molecular mechanisms through which dendritic cells (DCs) prime T helper 2 (Th2) responses, including those elicited by parasitic helminths, remain incompletely understood. Here, we report that soluble egg antigen...