Leonard Khiroug
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Explore the profile of Leonard Khiroug including associated specialties, affiliations and a list of published articles.
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43
Citations
1499
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Recent Articles
1.
Fedotova A, Brazhe A, Doronin M, Toptunov D, Pryazhnikov E, Khiroug L, et al.
Function (Oxf)
. 2023 Jun;
4(4):zqad019.
PMID: 37342415
Locomotion triggers a coordinated response of both neurons and astrocytes in the brain. Here we performed calcium (Ca) imaging of these two cell types in the somatosensory cortex in head-fixed...
2.
Bespalov A, Courade J, Khiroug L, Terstappen G, Wang Y
Drug Discov Today
. 2022 Aug;
27(11):103338.
PMID: 35973661
Significant efforts have been channeled into developing antibodies for the treatment of CNS indications. Disappointment with the first generation of clinical Tau antibodies in Alzheimer's disease has highlighted the challenges...
3.
Khiroug L, Verkhratsky A
Cell Calcium
. 2021 Aug;
98:102452.
PMID: 34399234
The 25-century long history of brain science can be divided into four distinct 'Eras': Era 1 (∼2000 years) started around 500 BC with reductionist studies of human and animal brains...
4.
Sun W, Suzuki K, Toptunov D, Stoyanov S, Yuzaki M, Khiroug L, et al.
Front Neurosci
. 2019 May;
13:421.
PMID: 31133777
Two-photon imaging of fluorescently labeled microglia provides a direct approach to measure motility of microglial processes as a readout of microglial function that is crucial in the context of neurodegenerative...
5.
Pradier L, Blanchard-Bregeon V, Bohme A, Debeir T, Menager J, Benoit P, et al.
Alzheimers Res Ther
. 2018 Nov;
10(1):117.
PMID: 30486882
Background: Anti-amyloid β (Aβ) immunotherapy represents a major area of drug development for Alzheimer's disease (AD). However, Aβ peptide adopts multiple conformations and the pathological forms to be specifically targeted...
6.
Leimuranta P, Khiroug L, Giniatullin R
Front Pharmacol
. 2018 May;
9:420.
PMID: 29740328
In this mini-review, we summarize recent discoveries and present new hypotheses on the role of cannabinoids in controlling trigeminal nociceptive system underlying migraine pain. Individual sections of this review cover...
7.
Pryazhnikov E, Mugantseva E, Casarotto P, Kolikova J, Fred S, Toptunov D, et al.
Sci Rep
. 2018 Apr;
8(1):6464.
PMID: 29691465
Ketamine, a well-known anesthetic, has recently attracted renewed attention as a fast-acting antidepressant. A single dose of ketamine induces rapid synaptogenesis, which may underlie its antidepressant effect. To test whether...
8.
Cui L, Nitzsche F, Pryazhnikov E, Tibeykina M, Tolppanen L, Rytkonen J, et al.
Stroke
. 2017 Sep;
48(10):2895-2900.
PMID: 28916665
Background And Purpose: Very late antigen-4 (integrin α4β1)/vascular cell adhesion molecule-1 mediates leukocyte trafficking and transendothelial migration after stroke. Mesenchymal stem cells (MSCs) typically express integrin β1 but insufficient ITGA4...
9.
Markkanen M, Ludwig A, Khirug S, Pryazhnikov E, Soni S, Khiroug L, et al.
Brain Res
. 2017 Sep;
1675:87-101.
PMID: 28888841
The neuron-specific K-Cl cotransporter KCC2 maintains the low intracellular chloride concentration required for the fast hyperpolarizing responses of the inhibitory neurotransmitters γ-aminobutyric acid (GABA) and glycine. The two KCC2 isoforms,...
10.
Antila H, Ryazantseva M, Popova D, Sipila P, Guirado R, Kohtala S, et al.
Sci Rep
. 2017 Aug;
7(1):7811.
PMID: 28798343
A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show...