Leonard Howell
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Explore the profile of Leonard Howell including associated specialties, affiliations and a list of published articles.
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20
Citations
276
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Recent Articles
1.
Li C, Tong F, Kempf D, Howell L, Zhang X
Curr Res Neurobiol
. 2023 Jul;
5:100097.
PMID: 37404949
Background: Somatosensory deficits are frequently seen in acute stroke patients and may recover over time and affect functional outcome. However, the underlying mechanism of function recovery remains poorly understood. In...
2.
Li C, Meng Y, Yan Y, Kempf D, Howell L, Tong F, et al.
Investig Magn Reson Imaging
. 2023 Jan;
26(4):275-283.
PMID: 36698483
Background: Investigation of stroke lesion has mostly focused on grey matter (GM) in previous studies and white matter (WM) degeneration during acute stroke is understudied. In the present study, monkeys...
3.
Li C, Kempf D, Howell L, Zhang X
Magn Reson Imaging
. 2020 Oct;
75:134-140.
PMID: 33127411
Objective: Alfaxalone has been used increasingly in biomedical research and veterinary medicine of large animals in recent years. However, its effects on the cerebral blood flow (CBF) physiology and intrinsic...
4.
Joers V, Masilamoni G, Kempf D, Weiss A, Rotterman T, Murray B, et al.
Neurobiol Dis
. 2020 Jul;
144:105027.
PMID: 32712266
Inflammation has been linked to the development of nonmotor symptoms in Parkinson's disease (PD), which greatly impact patients' quality of life and can often precede motor symptoms. Suitable animal models...
5.
Zhang X, Yan Y, Tong F, Li C, Jones B, Wang S, et al.
Open Neuroimag J
. 2018 May;
12:30-41.
PMID: 29785226
Background: Previous Diffusion Tensor Imaging (DTI) studies have demonstrated the temporal evolution of stroke injury in grey matter and white matter can be characterized by DTI indices. However, it still...
6.
Zeng F, Nye J, Voll R, Howell L, Goodman M
ACS Med Chem Lett
. 2018 Mar;
9(3):188-192.
PMID: 29541358
Nine pyridyloxypyridyl indole carboxamides were synthesized and displayed high affinities for 5-HT receptors and high selectivity over 5-HT and 5-HT. Among them, 6-methyl--[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]1-indole-3-carboxamide () exhibits the highest 5-HT binding affinity...
7.
Raper J, Morrison R, Daniels J, Howell L, Bachevalier J, Wichmann T, et al.
ACS Chem Neurosci
. 2017 Mar;
8(7):1570-1576.
PMID: 28324647
The use of Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) in neuroscience has rapidly expanded in rodent studies but has lagged behind in nonhuman primate (NHP) experiments, slowing the...
8.
Gopinath K, Maltbie E, Urushino N, Kempf D, Howell L
Psychopharmacology (Berl)
. 2016 Aug;
233(21-22):3673-3684.
PMID: 27530989
Rationale: There is a significant interest in the NMDA-receptor antagonist ketamine due to its efficacy in treating depressive disorders and its induction of psychotic-like symptoms that make it a useful...
9.
Maltbie E, Gopinath K, Urushino N, Kempf D, Howell L
Psychopharmacology (Berl)
. 2015 Dec;
233(6):961-72.
PMID: 26660447
Rationale: There is significant interest in the NMDA receptor antagonist ketamine due to its efficacy in treating depressive disorders and its induction of psychotic-like symptoms that make it a useful...
10.
Zhang X, Tong F, Li C, Yan Y, Kempf D, Nair G, et al.
PLoS One
. 2015 Feb;
10(2):e0117290.
PMID: 25659092
Background And Purpose: Diffusion-weighted imaging (DWI) and perfusion MRI were used to examine the spatiotemporal evolution of stroke lesions in adult macaques with ischemic occlusion. Methods: Permanent MCA occlusion was...