Leonam Gomes Coutinho
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Explore the profile of Leonam Gomes Coutinho including associated specialties, affiliations and a list of published articles.
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8
Citations
79
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Recent Articles
1.
Oliveira T, Coutinho L, de Oliveira L, de Souza Timoteo A, Farias G, Agnez-Lima L
Front Immunol
. 2022 Mar;
13:793096.
PMID: 35296074
Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional enzyme that is essential for maintaining cellular homeostasis. APE1 is the major apurinic/apyrimidinic endonuclease in the base excision repair pathway...
2.
Oliveira T, Fontes-Dantas F, de Medeiros Oliveira R, Pinheiro D, Coutinho L, da Silva V, et al.
Front Cell Dev Biol
. 2021 Oct;
9:731588.
PMID: 34616737
The presence of oxidized DNA lesions, such as 7,8-dihydro-8-oxoguanine (8-oxoG) and apurinic/apyrimidinic sites (AP sites), has been described as epigenetic signals that are involved in gene expression control. In mammals,...
3.
Pinheiro D, de Oliveira A, Coutinho L, Fontes F, de Medeiros Oliveira R, Oliveira T, et al.
Free Radic Biol Med
. 2018 Oct;
130:8-22.
PMID: 30366059
Oxidative stress generated during inflammation is associated with a wide range of pathologies. Resveratrol (RESV) displays anti-inflammatory and antioxidant activities, being a candidate for the development of adjuvant therapies for...
4.
Fontes F, de Araujo L, Coutinho L, Leib S, Agnez-Lima L
BMC Med Genet
. 2015 Aug;
16:70.
PMID: 26316174
Background: Bacterial meningitis (BM) is an infectious disease that results in high mortality and morbidity. Despite efficacious antibiotic therapy, neurological sequelae are often observed in patients after disease. Currently, the...
5.
Tavares L, Cavalcante K, Soares Campelo M, Coutinho L, Batistuzzo de Medeiros S, Guimaraes S, et al.
Acta Cir Bras
. 2014 Aug;
29(8):538-43.
PMID: 25140597
Purpose: To investigate whether there is any effect resulting from preconditioning with nutraceutical supplementation containing arginine and oil mixes with high ω9:ω6 ratio and low ω6:ω3 ratio containing EPA and...
6.
Silva T, Fontes F, Coutinho L, Souza F, de Melo J, de Souto J, et al.
Mutat Res
. 2011 Jun;
713(1-2):39-47.
PMID: 21651918
In vitro and in animal models, APE1, OGG1, and PARP-1 have been proposed as being involved with inflammatory response. In this work, we have investigated if the SNPs APE1 Asn148Glu,...
7.
Souza F, Fontes F, Silva T, Coutinho L, Leib S, Agnez-Lima L
BMC Med Genet
. 2011 Apr;
12:51.
PMID: 21473761
Background: The kynurenine (KYN) pathway has been shown to be altered in several diseases which compromise the central nervous system (CNS) including infectious diseases such as bacterial meningitis (BM). The...
8.
da Silva W, Pinheiro A, Coutinho L, Marinho L, Fassarella Agnez Lima L
Rev Soc Bras Med Trop
. 2010 Aug;
43(4):455-7.
PMID: 20802949
Introduction: Acute bacterial meningitis (ABM) remains a public health problem in Brazil. To evaluate the epidemiology of ABM cases at Giselda Trigueiro Hospital, Rio Grande do Norte, a descriptive retrospective...