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Leon Schurgers

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Articles 57
Citations 1728
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Recent Articles
11.
Aberger S, Findenig B, Beil J, Aichinger N, Koller J, Vermeer C, et al.
Acta Derm Venereol . 2023 Jul; 103:adv5755. PMID: 37428027
Calciphylaxis is a rare, yet underdiagnosed condition causing high mortality in patients with severe renal and cardiovascular disease. Since knowledge of the pathophysiology of calciphylaxis is limited, a differential analysis...
12.
Saritas T, Reinartz S, Kruger T, Ketteler M, Liangos O, Labriola L, et al.
Clin Kidney J . 2023 May; 15(12):2300-2311. PMID: 37216675
Background: Cardiovascular calcifications are prevented by matrix Gla protein (MGP), a vitamin K-dependent protein. Haemodialysis patients exhibit marked vitamin K deficiency. The randomized, prospective, open-label, multicentre VitaVasK trial analysed whether...
13.
Wang R, Damanik F, Kuhnt T, Jaminon A, Hafeez S, Liu H, et al.
Adv Healthc Mater . 2023 Mar; 12(17):e2202648. PMID: 36864621
Digital light processing (DLP) is an accurate and fast additive manufacturing technique to produce a variety of products, from patient-customized biomedical implants to consumer goods. However, DLP's use in tissue...
14.
Dzhanaev R, Hasberg C, Gorgels A, Schmitz C, Winkler C, Malyaran H, et al.
Theranostics . 2023 Jan; 13(2):659-672. PMID: 36632229
Calcium plays an essential role in the biology of vertebrates. Calcium content in body fluids is maintained within a narrow physiologic range by feedback control. Phosphate is equally important for...
15.
Fontaine M, Jin H, Gagliardi M, Rousch M, Wijnands E, Stoll M, et al.
Adv Sci (Weinh) . 2022 Dec; 10(5):e2203053. PMID: 36526599
Acute myocardial infarction (AMI) is accompanied by a systemic trauma response that impacts the whole body, including blood. This study addresses whether macrophages, key players in trauma repair, sense and...
16.
Nagy M, van der Meijden P, Glunz J, Schurgers L, Lutgens E, Ten Cate H, et al.
Pharmaceuticals (Basel) . 2022 Nov; 15(11). PMID: 36422558
Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis, is underdiagnosed in the general population. Despite the extensive research performed to unravel its pathophysiology, inadequate knowledge exists, thus preventing the...
17.
Pavlic A, Bahram Sangani N, Kerins J, Nicolaes G, Schurgers L, Reutelingsperger C
Int J Mol Sci . 2022 Aug; 23(16). PMID: 36012444
Vascular calcification (VC) is the pathological precipitation of calcium salts in the walls of blood vessels. It is a risk factor for cardiovascular events and their associated mortality. VC can...
18.
Kuppe C, Ramirez Flores R, Li Z, Hayat S, Levinson R, Liao X, et al.
Nature . 2022 Aug; 608(7924):766-777. PMID: 35948637
Myocardial infarction is a leading cause of death worldwide. Although advances have been made in acute treatment, an incomplete understanding of remodelling processes has limited the effectiveness of therapies to...
19.
Ebert T, Tran N, Schurgers L, Stenvinkel P, Shiels P
Mol Aspects Med . 2022 Jun; 86:101099. PMID: 35689974
Post-translational modifications (PTMs) have been proposed as a link between the oxidative stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing. Phosphorylation, acetylation, and ubiquitination cover >90% of all the reported...
20.
Viegas C, Araujo N, Carreira J, Pontes J, Macedo A, Vinhas M, et al.
Int J Mol Sci . 2022 May; 23(9). PMID: 35563203
Chronic inflammation is a major driver of chronic inflammatory diseases (CIDs), with a tremendous impact worldwide. Besides its function as a pathological calcification inhibitor, vitamin K-dependent protein Gla-rich protein (GRP)...