Leon F McSwain
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Explore the profile of Leon F McSwain including associated specialties, affiliations and a list of published articles.
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8
Citations
91
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Recent Articles
1.
Li Y, Lim C, Dismuke T, Malawsky D, Oasa S, Bruce Z, et al.
Nat Commun
. 2025 Feb;
16(1):1091.
PMID: 39904981
OLIG2-expressing tumor stem cells have been shown to drive recurrence in Sonic Hedgehog (SHH)-subgroup medulloblastoma (MB) and patients urgently need specific therapies to target this tumor cell population. Here, we...
2.
Smart S, Yeung T, Santos M, McSwain L, Wang X, Frye S, et al.
Cancers (Basel)
. 2024 Aug;
16(16).
PMID: 39199601
Outcomes are poor in patients with advanced or relapsed Ewing sarcoma (EWS) and current treatments have significant short- and long-term side effects. New, less toxic and more effective treatments are...
3.
Shahab S, Roggeveen C, Sun J, Kunhiraman H, McSwain L, Juraschka K, et al.
Mol Oncol
. 2023 Jun;
17(9):1784-1802.
PMID: 37341142
Children with Group 3 medulloblastoma (G3 MB) have a very poor prognosis, and many do not survive beyond 5 years after diagnosis. A factor that may contribute to this is...
4.
McSwain L, Pillsbury C, Haji-Seyed-Javadi R, Rath S, Chen V, Huang T, et al.
Sci Rep
. 2023 Jun;
13(1):9717.
PMID: 37322047
No abstract available.
5.
McSwain L, Pillsbury C, Haji-Seyed-Javadi R, Rath S, Chen V, Huang T, et al.
Sci Rep
. 2023 May;
13(1):8087.
PMID: 37208357
Y-box binding protein 1 (YBX1 or YB1) is a therapeutically relevant oncoprotein capable of RNA and DNA binding and mediating protein-protein interactions that drive proliferation, stemness, and resistance to platinum-based...
6.
McSwain L, Parwani K, Shahab S, Hambardzumyan D, MacDonald T, Spangle J, et al.
Front Oncol
. 2022 Jun;
12:903830.
PMID: 35747808
Medulloblastoma (MB) is the most common malignant brain tumor in children with standard of care consisting of surgery, radiation, and chemotherapy. Recent molecular profiling led to the identification of four...
7.
Yuan L, Zhang H, Liu J, Malhotra A, Dey A, Yu B, et al.
Mol Oncol
. 2021 Sep;
16(4):1009-1025.
PMID: 34482626
Sonic hedgehog (Shh)-driven medulloblastoma (Shh MB) cells are dependent on constitutive Shh signaling, but targeted treatment of Shh MB has been ineffective due to drug resistance. The purpose of this...
8.
Malpe M, McSwain L, Kudyba K, Ng C, Nicholson J, Brady M, et al.
Sci Rep
. 2020 Mar;
10(1):3888.
PMID: 32127590
Adult stem cells divide to renew the stem cell pool and replenish specialized cells that are lost due to death or usage. However, little is known about the mechanisms regulating...
9.
Kaffes I, Szulzewsky F, Chen Z, Herting C, Gabanic B, Velazquez Vega J, et al.
Oncoimmunology
. 2019 Oct;
8(11):e1655360.
PMID: 31646100
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor in adults, with a median survival of 14.6 months. Recent efforts have focused on identifying clinically relevant subgroups to improve...