Leng-Siew Yeap
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Explore the profile of Leng-Siew Yeap including associated specialties, affiliations and a list of published articles.
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22
Citations
813
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Recent Articles
1.
Dai P, Tan Y, Luo Y, Liu T, Huang Y, Shang Y, et al.
Mol Cell
. 2025 Mar;
PMID: 40049162
In adaptive immunity, transcription-coupled damage (TCD) is introduced into antibody genes by activation-induced cytidine deaminase (AID) to diversify antibody repertoire. However, the coordination between transcription and DNA damage/repair remains elusive....
2.
Hao Q, Li J, Yeap L
Sci China Life Sci
. 2024 Jul;
67(11):2344-2353.
PMID: 39048716
Antibody diversification is essential for an effective immune response, with somatic hypermutation (SHM) serving as a key molecular process in this adaptation. Activation-induced cytidine deaminase (AID) initiates SHM by inducing...
3.
Wang Y, Meng F, Yeap L
Trends Immunol
. 2024 Feb;
45(3):167-176.
PMID: 38402044
Antibody-coding genes accumulate somatic mutations to achieve antibody affinity maturation. Genetic dissection using various mouse models has shown that intrinsic hypermutations occur preferentially and are predisposed in the DNA region...
4.
Huang M, Qin Y, Shang Y, Hao Q, Zhan C, Lian C, et al.
Nat Cell Biol
. 2024 Jan;
26(2):294-304.
PMID: 38263276
Base editors (BEs) introduce base substitutions without double-strand DNA cleavage. Besides precise substitutions, BEs generate low-frequency 'stochastic' byproducts through unclear mechanisms. Here, we performed in-depth outcome profiling and genetic dissection,...
5.
Wang Y, Zhang S, Zheng X, Yeap L, Meng F
STAR Protoc
. 2023 Sep;
4(4):102602.
PMID: 37742176
Cytidine deaminases as DNA mutators play important roles in immunity and genome stability. Here, we present a high-throughput protocol for deamination of long single-stranded (ss) DNA or oligo pools containing...
6.
Wang Y, Zhang S, Yang X, Hwang J, Zhan C, Lian C, et al.
Cell
. 2023 Apr;
186(10):2193-2207.e19.
PMID: 37098343
Somatic hypermutation (SHM), initiated by activation-induced cytidine deaminase (AID), generates mutations in the antibody-coding sequence to allow affinity maturation. Why these mutations intrinsically focus on the three nonconsecutive complementarity-determining regions...
7.
Hao Q, Zhan C, Lian C, Luo S, Cao W, Wang B, et al.
Sci Immunol
. 2023 Mar;
8(81):eade1167.
PMID: 36961908
Insertions and deletions (indels) are low-frequency deleterious genomic DNA alterations. Despite their rarity, indels are common, and insertions leading to long complementarity-determining region 3 (CDR3) are vital for antigen-binding functions...
8.
Gao B, He L, Bao Y, Chen Y, Lu G, Zhang Y, et al.
Cell Res
. 2023 Jan;
33(3):258-261.
PMID: 36697703
No abstract available.
9.
Feng A, Hao Q, Yeap L
Acta Biochim Biophys Sin (Shanghai)
. 2022 Jun;
54(6):820-827.
PMID: 35713319
Antibodies are important immune molecules that are elicited by B cells to protect our bodies during viral infections or vaccinations. In humans, the antibody repertoire is diversified by programmed DNA...
10.
Lin K, Zhou Y, Ai J, Wang Y, Zhang S, Qiu C, et al.
Emerg Microbes Infect
. 2022 Jan;
11(1):452-464.
PMID: 35045787
Breakthrough infection of SARS-CoV-2 is a serious challenge, as increased infections were documented in fully-vaccinated individuals. Recipients with poor antibody response are highly vulnerable to reinfection, whereas those with strong...