Lena Nenoff
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Explore the profile of Lena Nenoff including associated specialties, affiliations and a list of published articles.
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16
Citations
166
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Recent Articles
1.
Bookbinder A, Bobic M, Sharp G, Nenoff L
Phys Med Biol
. 2024 Jul;
69(17).
PMID: 39047780
. This study describes geometry-based and intensity-based tools for quality assurance (QA) of automatically generated structures for online adaptive radiotherapy, and designs an operator-independent traffic light system that identifies erroneous...
2.
Nenoff L, Amstutz F, Murr M, Archibald-Heeren B, Fusella M, Hussein M, et al.
Phys Med Biol
. 2023 Nov;
68(24).
PMID: 37972540
Deformable image registration (DIR) is a versatile tool used in many applications in radiotherapy (RT). DIR algorithms have been implemented in many commercial treatment planning systems providing accessible and easy-to-use...
3.
Nenoff L, Sudhyadhom A, Lau J, Sharp G, Paganetti H, Pursley J
Cancers (Basel)
. 2023 Sep;
15(18).
PMID: 37760560
With the availability of MRI linacs, online adaptive intensity modulated radiotherapy (IMRT) has become a treatment option for liver cancer patients, often combined with hypofractionation. Intensity modulated proton therapy (IMPT)...
4.
Bobic M, Lalonde A, Nesteruk K, Lee H, Nenoff L, Gorissen B, et al.
Clin Transl Radiat Oncol
. 2023 Apr;
40:100625.
PMID: 37090849
Purpose: This work evaluates an online adaptive (OA) workflow for head-and-neck (H&N) intensity-modulated proton therapy (IMPT) and compares it with full offline replanning (FOR) in patients with large anatomical changes....
5.
Nesteruk K, Bobic M, Sharp G, Lalonde A, Winey B, Nenoff L, et al.
Cancers (Basel)
. 2022 Oct;
14(20).
PMID: 36291939
Purpose: To evaluate the suitability of low-dose CT protocols for online plan adaptation of head-and-neck patients. Methods: We acquired CT scans of a head phantom with protocols corresponding to CT...
6.
Nenoff L, Buti G, Bobic M, Lalonde A, Nesteruk K, Winey B, et al.
Cancers (Basel)
. 2022 Aug;
14(16).
PMID: 36010919
Currently, adaptive strategies require time- and resource-intensive manual structure corrections. This study compares different strategies: optimization without manual structure correction, adaptation with physician-drawn structures, and no adaptation. Strategies were compared...
7.
Nenoff L, Matter M, Charmillot M, Krier S, Uher K, Weber D, et al.
Phys Med Biol
. 2021 Sep;
66(20).
PMID: 34587589
Anatomical changes during proton therapy require rapid treatment plan adaption to mitigate the associated dosimetric impact. This in turn requires a highly efficient workflow that minimizes the time between imaging...
8.
Amstutz F, Nenoff L, Albertini F, O Ribeiro C, Knopf A, Unkelbach J, et al.
Phys Med Biol
. 2021 Apr;
66(10).
PMID: 33862616
Deformable image registration (DIR) is an important component for dose accumulation and associated clinical outcome evaluation in radiotherapy. However, the resulting deformation vector field (DVF) is subject to unavoidable discrepancies...
9.
Nenoff L, Matter M, Amaya E, Josipovic M, Knopf A, Lomax A, et al.
Radiother Oncol
. 2021 Mar;
159:136-143.
PMID: 33771576
Purpose: A major burden of introducing an online daily adaptive proton therapy (DAPT) workflow is the time and resources needed to correct the daily propagated contours. In this study, we...
10.
Nenoff L, O Ribeiro C, Matter M, Hafner L, Josipovic M, Langendijk J, et al.
Radiother Oncol
. 2020 May;
147:178-185.
PMID: 32380117
Background And Purpose: Non-small cell lung cancer (NSCLC) patients show typically large anatomical changes during treatment, making recalculation or adaption necessary. For report and review, the applied treatment dose can...