Lejla Medzikovic
Overview
Explore the profile of Lejla Medzikovic including associated specialties, affiliations and a list of published articles.
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25
Citations
376
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Recent Articles
1.
Hatamnejad M, Medzikovic L, Dehghanitafti A, Rahman B, Vadgama A, Eghbali M
Int J Mol Sci
. 2025 Mar;
26(5).
PMID: 40076864
The effect of the gut microbiota extends beyond their habitant place from the gastrointestinal tract to distant organs, including the cardiovascular system. Research interest in the relationship between the heart...
2.
Ruffenach G, Medzikovic L, Aryan L, Sun W, Lertpanit L, OConnor E, et al.
Respir Res
. 2024 Nov;
25(1):419.
PMID: 39609844
Objectives: Pulmonary arterial hypertension (PAH) is characterized by the remodeling of the pulmonary vascular bed leading to elevation of the pulmonary arterial pressure. Oxidized fatty acids, such as hydroxyeicosatetraenoic acids...
3.
Transcriptome analyses reveal common immune system dysregulation in PAH patients and -deficient rats
Ruffenach G, Le Ribeuz H, Dutheil M, El Jekmek K, Dumont F, Willer A, et al.
Pulm Circ
. 2024 Oct;
14(4):e12434.
PMID: 39444497
Pulmonary arterial hypertension (PAH) is a severe disease caused by progressive distal pulmonary artery obstruction. One cause of PAH are loss-of-function mutations in the potassium channel subfamily K member 3...
4.
Hong J, Medzikovic L, Sun W, Wong B, Ruffenach G, Rhodes C, et al.
Circulation
. 2024 Aug;
150(16):1268-1287.
PMID: 39167456
Background: Integrative multiomics can elucidate pulmonary arterial hypertension (PAH) pathobiology, but procuring human PAH lung samples is rare. Methods: We leveraged transcriptomic profiling and deep phenotyping of the largest multicenter...
5.
Ruffenach G, Medzikovic L, Sun W, Hong J, Eghbali M
Cells
. 2023 Dec;
12(24).
PMID: 38132114
Gene expression is under tight regulation from the chromatin structure that regulates gene accessibility by the transcription machinery to protein degradation. At the transcript level, this regulation falls on RNA-binding...
6.
Medzikovic L, Azem T, Sun W, Rejali P, Esdin L, Rahman S, et al.
Cells
. 2023 Aug;
12(16).
PMID: 37626887
Mortality from myocardial infarction (MI) has declined over recent decades, which could be attributed in large part to improved treatment methods. Early reperfusion is the cornerstone of current MI treatment....
7.
Medzikovic L, Aryan L, Ruffenach G, Li M, Savalli N, Sun W, et al.
JCI Insight
. 2023 May;
8(9).
PMID: 37154157
Myocardial fibrosis and calcification associate with adverse outcomes in nonischemic heart failure. Cardiac fibroblasts (CF) transition into myofibroblasts (MF) and osteogenic fibroblasts (OF) to promote myocardial fibrosis and calcification. However,...
8.
Banerjee S, Zargari M, Medzikovic L, Russino H, Mikhael M, Koons N, et al.
Br J Anaesth
. 2022 Dec;
130(2):e183-e187.
PMID: 36462942
No abstract available.
9.
Ruffenach G, Medzikovic L, Aryan L, Li M, Eghbali M
Circulation
. 2022 Aug;
146(16):1243-1258.
PMID: 35993245
Background: RNA-binding proteins are master orchestrators of gene expression regulation. They regulate hundreds of transcripts at once by recognizing specific motifs. Thus, characterizing RNA-binding proteins targets is critical to harvest...
10.
Cunningham C, Li M, Ruffenach G, Doshi M, Aryan L, Hong J, et al.
Am J Respir Crit Care Med
. 2022 May;
206(2):186-196.
PMID: 35504005
Idiopathic pulmonary arterial hypertension (PAH) is a terminal pulmonary vascular disease characterized by increased pressure, right ventricular failure, and death. PAH exhibits a striking sex bias and is up to...