Lee Faulkner
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Explore the profile of Lee Faulkner including associated specialties, affiliations and a list of published articles.
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32
Citations
572
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Recent Articles
1.
Strike W, Amirsoleimani A, Olaleye A, Noble A, Lewis K, Faulkner L, et al.
ACS ES T Water
. 2023 Aug;
2(11):1984-1991.
PMID: 37552725
Over the course of the COVID-19 pandemic, wastewater surveillance has become a useful tool for describing SARS-CoV-2 prevalence in populations of varying size, from individual facilities (e.g., university residence halls,...
2.
Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds
Ogese M, Watkinson J, Lister A, Faulkner L, Gibson A, Hillegas A, et al.
Toxicol Sci
. 2020 Mar;
175(2):266-278.
PMID: 32159798
The prediction of drug hypersensitivity is difficult due to the lack of appropriate models and known risk factors. In vitro naïve T-cell priming assays that assess immunogenicity have been developed....
3.
Ogese M, Jenkins R, Adair K, Tailor A, Meng X, Faulkner L, et al.
Hepatology
. 2019 May;
70(5):1732-1749.
PMID: 31070244
Idiosyncratic drug-induced liver injury (DILI) is a rare, often difficult-to-predict adverse reaction with complex pathomechanisms. However, it is now evident that certain forms of DILI are immune-mediated and may involve...
4.
Usui T, Tailor A, Faulkner L, Meng X, Farrell J, Daly A, et al.
Chem Res Toxicol
. 2018 Sep;
31(10):1022-1024.
PMID: 30179004
The HLA class I allele HLA-A*33:03 is a risk factor for ticlopidine-induced liver injury. Herein, we show HLA class I-restricted ticlopidine-specific CD8+ T-cell activation in healthy donors expressing HLA-A*33:03. Cloned...
5.
Usui T, Faulkner L, Farrell J, French N, Alfirevic A, Pirmohamed M, et al.
Chem Res Toxicol
. 2018 Feb;
31(3):165-167.
PMID: 29436218
It is unclear whether priming of naïve T cells to drugs is detectable in healthy human donors expressing different human leukocyte antigen (HLA) alleles. Thus, we examined T cell priming...
6.
Gibson A, Faulkner L, Lichtenfels M, Ogese M, Al-Attar Z, Alfirevic A, et al.
J Immunol
. 2018 Feb;
200(5):1951.
PMID: 29427416
No abstract available.
7.
Amali M, Jenkins R, Meng X, Faulkner L, Whitaker P, Peckham D, et al.
Chem Res Toxicol
. 2017 Nov;
30(12):2097-2099.
PMID: 29148816
The risk of developing hypersensitivity to alternative antibiotics is a concern for penicillin hypersensitive patients and healthcare providers. Herein we use piperacillin hypersensitivity as a model to explore the reactivity...
8.
Gibson A, Faulkner L, Lichtenfels M, Ogese M, Al-Attar Z, Alfirevic A, et al.
J Immunol
. 2017 Jul;
199(4):1223-1237.
PMID: 28687658
Drug hypersensitivity involves the activation of T cells in an HLA allele-restricted manner. Because the majority of individuals who carry HLA risk alleles do not develop hypersensitivity, other parameters must...
9.
Ogese M, Faulkner L, Jenkins R, French N, Copple I, Antoine D, et al.
Toxicol Sci
. 2017 Apr;
158(1):76-89.
PMID: 28444390
It is now apparent that antigen-specific T-cells are activated in certain patients with drug-induced liver injury (DILI). Since cross-talk between hepatocytes and immune cells is likely to be critical in...
10.
Sullivan A, Wang E, Farrell J, Whitaker P, Faulkner L, Peckham D, et al.
J Allergy Clin Immunol
. 2017 Feb;
141(1):235-249.e8.
PMID: 28219704
Background: β-Lactam hypersensitivity has been classified according to the phenotype and function of drug-specific T cells. However, new T-cell subsets have not been considered. Objective: The objective of this study...