Leda Roche
Overview
Explore the profile of Leda Roche including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
236
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Recent Articles
1.
Corvo I, Ferraro F, Merlino A, Zuberbuhler K, ODonoghue A, Pastro L, et al.
Front Mol Biosci
. 2018 May;
5:40.
PMID: 29725596
Cysteine proteases are widespread in all life kingdoms, being central to diverse physiological processes based on a broad range of substrate specificity. Paralogous cathepsin L proteases are essential to parasite...
2.
Cancela M, Corvo I, DA Silva E, Teichmann A, Roche L, Diaz A, et al.
Parasitology
. 2017 Jul;
144(13):1695-1707.
PMID: 28697819
Cystatins are small, phylogenetically conserved proteins that are tight-binding inhibitors of cysteine proteinases. The liver fluke Fasciola hepatica uses a diverse set of cysteine proteinases of the papain superfamily for...
3.
Tapie A, Pi-Denis N, Souto J, Vomero A, Peluffo G, Boidi M, et al.
Clin Case Rep
. 2017 Feb;
5(2):170-174.
PMID: 28174645
Mutations in ARX gene should be considered in patients with mental disability or/and epilepsy. It is an X-linked gene that has pleiotropic effects. Here, we report the case of a...
4.
Gonzalez G, Raggio V, Boidi M, Tapie A, Roche L
Rev Neurol
. 2013 Jul;
57 Suppl 1:S75-83.
PMID: 23897159
Despite the advances made in the field of genetics, neuroimaging and metabolic diseases, half the children with mental retardation remain without an aetiological diagnosis. A genetic base is estimated to...
5.
Corvo I, ODonoghue A, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, et al.
PLoS Negl Trop Dis
. 2013 Jul;
7(7):e2269.
PMID: 23875031
Background: A family of secreted cathepsin L proteases with differential activities is essential for host colonization and survival in the parasitic flatworm Fasciola hepatica. While the blood feeding adult secretes...
6.
Maggioli G, Acosta D, Silveira F, Rossi S, Giacaman S, Basika T, et al.
Vaccine
. 2011 Sep;
29(48):9057-63.
PMID: 21939713
Fasciola hepatica M17 leucine aminopeptidase (FhLAP) is thought to play a role in catabolizing peptides generated by the concerted activity of gut-associated endopeptidases on host polypeptides, thus releasing amino acids...
7.
Robinson M, Corvo I, Jones P, George A, Padula M, To J, et al.
PLoS Negl Trop Dis
. 2011 Apr;
5(4):e1012.
PMID: 21483711
Background: The temporal expression and secretion of distinct members of a family of virulence-associated cathepsin L cysteine peptidases (FhCL) correlates with the entry and migration of the helminth pathogen Fasciola...
8.
Cancela M, Ruetalo N, DellOca N, DA Silva E, Smircich P, Rinaldi G, et al.
BMC Genomics
. 2010 Apr;
11:227.
PMID: 20374642
Background: The common liver fluke Fasciola hepatica is the agent of a zoonosis with significant economic consequences in livestock production worldwide, and increasing relevance to human health in developing countries....
9.
Koziol U, Iriarte A, Castillo E, Soto J, Bello G, Cajarville A, et al.
Gene
. 2009 May;
443(1-2):1-11.
PMID: 19460422
Searching for hsp70 genes in Echinococcus granulosus, a divergent cytoplasmic hsp70-like sequence (EgpsiHsp70) was isolated, possessing a small truncation in the region coding for the C-terminal glycine-rich linker and EEVD-Ct...
10.
Corvo I, Cancela M, Cappetta M, Pi-Denis N, Tort J, Roche L
Mol Biochem Parasitol
. 2009 Apr;
167(1):41-7.
PMID: 19383516
Secreted cysteine proteases are major players in host-parasite interactions; in Fasciola hepatica, a distinct group of cathepsins L was found to be predominantly expressed in the juvenile stages, but their...