Lea Rems
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Explore the profile of Lea Rems including associated specialties, affiliations and a list of published articles.
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25
Citations
446
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Recent Articles
1.
Batista Napotnik T, Kos B, Rems L
J Vis Exp
. 2024 Sep;
(211).
PMID: 39311601
Excitable cells such as neuronal and muscle cells can be primary targets in rapidly emerging electroporation-based treatments. However, they can be affected by electric pulses even in therapies where they...
2.
Blazic A, Guinard M, Leskovar T, OConnor R, Rems L
Bioelectrochemistry
. 2024 Sep;
161:108802.
PMID: 39243733
Electroporation causes a temporal increase in cell membrane permeability and leads to prolonged changes in transmembrane voltage (TMV) in both excitable and non-excitable cells. However, the mechanisms of these TMV...
3.
Scuderi M, Dermol-Cerne J, Scancar J, Markovic S, Rems L, Miklavcic D
Radiol Oncol
. 2024 Feb;
58(1):51-66.
PMID: 38378034
Background: Electrochemotherapy (ECT) is a treatment involving the administration of chemotherapeutics drugs followed by the application of 8 square monopolar pulses of 100 μs duration at a repetition frequency of...
4.
Batista Napotnik T, Kos B, Jarm T, Miklavcic D, OConnor R, Rems L
Sci Rep
. 2024 Jan;
14(1):720.
PMID: 38184741
Electric pulses used in electroporation-based treatments have been shown to affect the excitability of muscle and neuronal cells. However, understanding the interplay between electroporation and electrophysiological response of excitable cells...
5.
Rems L, Rainot A, Wiczew D, Szulc N, Tarek M
Bioelectrochemistry
. 2023 Oct;
155:108588.
PMID: 37879163
Recent studies showed that nanosecond pulsed electric fields (nsPEFs) can activate voltage-gated ion channels (VGICs) and trigger action potentials (APs) in excitable cells. Under physiological conditions, VGICs' activation takes place...
6.
Scuderi M, Dermol-Cerne J, Batista Napotnik T, Chaigne S, Bernus O, Benoist D, et al.
Biomolecules
. 2023 May;
13(5).
PMID: 37238597
Electroporation is a biophysical phenomenon involving an increase in cell membrane permeability to molecules after a high-pulsed electric field is applied to the tissue. Currently, electroporation is being developed for...
7.
Vindis T, Blazic A, Khayyat D, Potocnik T, Sachdev S, Rems L
Pharmaceutics
. 2022 Sep;
14(9).
PMID: 36145709
Gene electrotransfer is one of the main non-viral methods for intracellular delivery of plasmid DNA, wherein pulsed electric fields are used to transiently permeabilize the cell membrane, allowing enhanced transmembrane...
8.
Scuderi M, Dermol-Cerne J, Amaral da Silva C, Muralidharan A, Boukany P, Rems L
Bioelectrochemistry
. 2022 Aug;
147:108216.
PMID: 35932533
Electroporation has become a powerful tool for nonviral delivery of various biomolecules such as nucleic acids, proteins, and chemotherapeutic drugs to virtually any living cell by exposing the cell membrane...
9.
Muralidharan A, Pesch G, Hubbe H, Rems L, Nouri-Goushki M, Boukany P
Bioelectrochemistry
. 2022 Jul;
147:108197.
PMID: 35810498
We developed a localized single-cell electroporation chip to deliver exogenous biomolecules with high efficiency while maintaining high cell viability. In our microfluidic device, the cells are trapped in a microtrap...
10.
Rems L, Tang X, Zhao F, Perez-Conesa S, Testa I, Delemotte L
Elife
. 2022 Feb;
11.
PMID: 35195069
The plasma membrane of a biological cell is a complex assembly of lipids and membrane proteins, which tightly regulate transmembrane transport. When a cell is exposed to strong electric field,...