Lawrence R Kleinberg
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Explore the profile of Lawrence R Kleinberg including associated specialties, affiliations and a list of published articles.
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72
Citations
3488
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Recent Articles
1.
LeCompte M, Vuppala N, Reyes J, Page B, Croog V, Huang E, et al.
Neurooncol Adv
. 2025 Feb;
7(1):vdaf004.
PMID: 39991181
Background: The optimal regimen, normal tissue tolerances, and appropriate indications for reirradiation for recurrent high-grade glioma (HGG) are uncertain. The aim of this study was to determine whether higher reirradiation...
2.
Holdhoff M, Ye X, Strowd R, Nabors B, Walbert T, Lieberman F, et al.
Neurooncol Adv
. 2024 Oct;
6(1):vdae150.
PMID: 39371261
Background: Lisavanbulin (BAL101553) is a small, lipophilic, oral microtubule destabilizer with promising antitumoral activity observed in preclinical glioblastoma (GBM) models. Methods: This multicenter phase 1 study sought to determine the...
3.
Sloan L, Sen R, Liu C, Doucet M, Blosser L, Katulis L, et al.
Front Immunol
. 2024 Sep;
15:1438044.
PMID: 39346903
Introduction: This is a prospective, rigorous inquiry into the systemic immune effects of standard adjuvant chemoradiotherapy, for WHO grade 4, glioblastoma. The purpose is to identify peripheral immunologic effects never...
4.
Rejimon A, Ramesh K, Trivedi A, Huang V, Schreibmann E, Weinberg B, et al.
Tomography
. 2024 Mar;
10(3):428-443.
PMID: 38535775
Current diagnostic and therapeutic approaches for gliomas have limitations hindering survival outcomes. We propose spectroscopic magnetic resonance imaging as an adjunct to standard MRI to bridge these gaps. Spectroscopic MRI...
5.
Bergerud K, Berkseth M, Pardoll D, Ganguly S, Kleinberg L, Lawrence J, et al.
Int J Radiat Oncol Biol Phys
. 2023 Dec;
119(1):42-55.
PMID: 38042450
Radiation therapy (RT) has been a primary treatment modality in cancer for decades. Increasing evidence suggests that RT can induce an immunosuppressive shift via upregulation of cells such as tumor-associated...
6.
Greenlund L, Shanley R, Mulford K, Neil E, Lawrence J, Arnold S, et al.
Front Immunol
. 2023 Nov;
14:1284118.
PMID: 38022656
Introduction: Treatment for glioblastomas, aggressive and nearly uniformly fatal brain tumors, provide limited long-term success. Immunosuppression by myeloid cells in both the tumor microenvironment and systemic circulation are believed to...
7.
Cao Y, Parekh V, Lee E, Chen X, Redmond K, Pillai J, et al.
Cancers (Basel)
. 2023 Aug;
15(16).
PMID: 37627141
We introduce tumor connectomics, a novel MRI-based complex graph theory framework that describes the intricate network of relationships within the tumor and surrounding tissue, and combine this with multiparametric radiomics...
8.
Ramesh K, Xu K, Trivedi A, Huang V, Sharghi V, Kleinberg L, et al.
Cancers (Basel)
. 2023 Aug;
15(15).
PMID: 37568773
Glioblastoma (GBM) has a poor survival rate even with aggressive surgery, concomitant radiation therapy (RT), and adjuvant chemotherapy. Standard-of-care RT involves irradiating a lower dose to the hyperintense lesion in...
9.
Trivedi A, Ramesh K, Huang V, Mellon E, Barker P, Kleinberg L, et al.
Cancers (Basel)
. 2023 Jul;
15(13).
PMID: 37444634
Despite aggressive treatment, glioblastoma has a poor prognosis due to its infiltrative nature. Spectroscopic MRI-measured brain metabolites, particularly the choline to N-acetylaspartate ratio (Cho/NAA), better characterizes the extent of tumor...
10.
Trivedi A, Kim S, Ramesh K, Giuffrida A, Weinberg B, Mellon E, et al.
Tomography
. 2023 May;
9(3):1052-1061.
PMID: 37218946
Accurate radiation therapy (RT) targeting is crucial for glioblastoma treatment but may be challenging using clinical imaging alone due to the infiltrative nature of glioblastomas. Precise targeting by whole-brain spectroscopic...